BOC cell adhesion associated, oncogene regulated | Elisa - Clia - Antibody - Protein

Background

BOC (Brother of CDO) is a cell surface receptor that belongs to the immunoglobulin (Ig)/fibronectin type III repeat family. It plays a critical role in cell adhesion and communication. BOC is prominently involved in the development of the central nervous system and muscle tissue, aiding in processes such as cell migration, differentiation, and axon guidance. The expression of BOC is dynamically regulated during development and in response to various oncogenic signals, suggesting its potential involvement in tumorigenesis.

Protein Structure

BOC is a transmembrane protein characterized by:

• Extracellular domain: Contains multiple immunoglobulin-like and fibronectin type III domains, which facilitate interactions with other cell surface proteins and extracellular matrix components.
• Transmembrane domain: Anchors the protein in the cell membrane.
• Intracellular domain: Involved in signal transduction, influencing intracellular pathways that regulate cell behavior.

Classification and Subtypes

BOC is part of the immunoglobulin superfamily and is closely related to CDO (Cell adhesion molecule-related/down-regulated by oncogenes). While BOC itself does not have subtypes, it is functionally and structurally related to other members of the immunoglobulin superfamily, particularly those involved in cell adhesion and signaling.

Function and Biological Significance

• Neural Development: BOC is crucial for the proper development of the nervous system, guiding axon pathfinding and neural circuit formation.
• Muscle Differentiation: It plays a role in myogenesis, facilitating the differentiation and fusion of muscle cells.
• Cell Adhesion: BOC mediates cell-cell interactions, which are essential for tissue organization and maintenance.
• Oncogenic Regulation: The expression of BOC is regulated by oncogenic signals, and it may be involved in the processes of tumor progression and metastasis.

Clinical Issues



• Cancer: Abnormal expression of BOC has been observed in various cancers, suggesting a role in tumorigenesis. Its interactions with oncogenic pathways make it a potential target for cancer therapy.
• Neurological Disorders: Given its role in neural development, mutations or dysregulation of BOC could contribute to developmental neurological disorders.
• Muscle Diseases: Disruptions in BOC function may affect muscle development and regeneration, potentially leading to muscle-related diseases.

Summary

BOC is a multifunctional cell surface receptor involved in crucial developmental processes such as neural and muscle development, as well as cell adhesion. Structurally characterized by immunoglobulin-like and fibronectin type III domains, BOC interacts with other cell surface proteins to mediate its effects. Its regulation by oncogenic signals highlights its potential involvement in cancer, making it a significant focus of research in oncology and developmental biology. Understanding BOC's roles and mechanisms can provide insights into therapeutic targets for cancer and other diseases related to its dysregulation.