Mouse Brother Of CDO Homolog (BOC) Protein

Product specifications

Proteins and Peptides

Brother Of CDO Homolog (BOC)

E. coli

Mouse

Unconjugated

Molecular Weight: Calculated MW: 25.9 kDa  Observed MW (SDS-PAGE): 23 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Lys668-Thr866
Tag: N-terminal His tag and GST tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

Q6AZB0

Boi,CDON2,Brother of CDO,Protein BOC

Protein BOC

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

BOC is a member of the immunoglobulin (Ig) superfamily and functions as a cell surface receptor involved in cell adhesion, axon guidance, and myogenic differentiation. It is predominantly expressed in neural and muscle tissues, where it interacts with other cell adhesion molecules and receptors to facilitate cell-cell communication and signaling. BOC plays a crucial role in the Hedgehog (Hh) signaling pathway by acting as a co-receptor for Sonic Hedgehog (Shh), enhancing its signaling and influencing developmental processes such as neural tube patterning and limb formation. Dysregulation of BOC has been linked to aberrant cell proliferation and migration, implicating its role in cancer progression and metastasis. Structurally, BOC contains multiple Ig-like domains and fibronectin type III repeats, which mediate its interactions with extracellular ligands and intracellular signaling molecules. Studies have shown that BOC modulates the balance between cell proliferation and differentiation, particularly in myogenic and neuronal contexts. It is also implicated in synaptic development and plasticity, supporting its diverse functional roles. Emerging research highlights its potential as a therapeutic target in cancers where Hedgehog signaling is dysregulated, such as basal cell carcinoma and medulloblastoma.

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