Brother of CDO Homolog (BOC) Antibody
442€ (200 µl)
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935106861
info@markelab.com
name
Brother of CDO Homolog (BOC) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431096
tested applications
P-ELISA, WB
Description
BOC Antibody is a Goat Polyclonal antibody against BOC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Brother of CDO Homolog (BOC) Immunogen: abx615488 - Internal region: C-TQEVKTSGSSDRLR |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 91653, 117606 |
| NCBI Accession | NP_150279.1 |
| Alias | Boi,CDON2,Brother of CDO,Protein BOC |
| Background | Antibody anti-BOC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
BOC is a member of the immunoglobulin (Ig) superfamily and functions as a cell surface receptor involved in cell adhesion, axon guidance, and myogenic differentiation. It is predominantly expressed in neural and muscle tissues, where it interacts with other cell adhesion molecules and receptors to facilitate cell-cell communication and signaling. BOC plays a crucial role in the Hedgehog (Hh) signaling pathway by acting as a co-receptor for Sonic Hedgehog (Shh), enhancing its signaling and influencing developmental processes such as neural tube patterning and limb formation. Dysregulation of BOC has been linked to aberrant cell proliferation and migration, implicating its role in cancer progression and metastasis. Structurally, BOC contains multiple Ig-like domains and fibronectin type III repeats, which mediate its interactions with extracellular ligands and intracellular signaling molecules. Studies have shown that BOC modulates the balance between cell proliferation and differentiation, particularly in myogenic and neuronal contexts. It is also implicated in synaptic development and plasticity, supporting its diverse functional roles. Emerging research highlights its potential as a therapeutic target in cancers where Hedgehog signaling is dysregulated, such as basal cell carcinoma and medulloblastoma.
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