Brother of CDO Homolog (BOC) Antibody
169€ (20 µl)
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935106861
info@markelab.com
name
Brother of CDO Homolog (BOC) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx320194
tested applications
ELISA, IHC
Description
BOC Antibody is a Rabbit Polyclonal against BOC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Brother of CDO Homolog (BOC) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BWV1 |
| Gene ID | 91653 |
| NCBI Accession | NP_001288790.1, NM_001301861.1, NP_150279.1, NM_033254.3 |
| OMIM | 608708 |
| Alias | Boi,CDON2,Brother of CDO,Protein BOC |
| Background | Antibody anti-BOC |
| Status | RUO |
Descripción
BOC is a member of the immunoglobulin (Ig) superfamily and functions as a cell surface receptor involved in cell adhesion, axon guidance, and myogenic differentiation. It is predominantly expressed in neural and muscle tissues, where it interacts with other cell adhesion molecules and receptors to facilitate cell-cell communication and signaling. BOC plays a crucial role in the Hedgehog (Hh) signaling pathway by acting as a co-receptor for Sonic Hedgehog (Shh), enhancing its signaling and influencing developmental processes such as neural tube patterning and limb formation. Dysregulation of BOC has been linked to aberrant cell proliferation and migration, implicating its role in cancer progression and metastasis. Structurally, BOC contains multiple Ig-like domains and fibronectin type III repeats, which mediate its interactions with extracellular ligands and intracellular signaling molecules. Studies have shown that BOC modulates the balance between cell proliferation and differentiation, particularly in myogenic and neuronal contexts. It is also implicated in synaptic development and plasticity, supporting its diverse functional roles. Emerging research highlights its potential as a therapeutic target in cancers where Hedgehog signaling is dysregulated, such as basal cell carcinoma and medulloblastoma.
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