Human Brother of CDO Homolog (BOC) Protein (Active)
247€ (10 µg)
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935106861
info@markelab.com
name
Human Brother of CDO Homolog (BOC) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx690641
tested applications
SDS-PAGE
Description
Human BOC Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Brother of CDO is produced by our Mammalian expression system and the target gene encoding Asp31-Ser157 is expressed with a 6His tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | BOC |
| Host | Human |
| Origin | Human |
| Observed MW | Molecular Weight: 14.2 kDa Sequence Fragment: Asp31-Ser157 Tag: C-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | PBS, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | Q96DN7 |
| Alias | Boi,CDON2,Brother of CDO,Protein BOC |
| Background | Protein BOC |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
BOC is a member of the immunoglobulin (Ig) superfamily and functions as a cell surface receptor involved in cell adhesion, axon guidance, and myogenic differentiation. It is predominantly expressed in neural and muscle tissues, where it interacts with other cell adhesion molecules and receptors to facilitate cell-cell communication and signaling. BOC plays a crucial role in the Hedgehog (Hh) signaling pathway by acting as a co-receptor for Sonic Hedgehog (Shh), enhancing its signaling and influencing developmental processes such as neural tube patterning and limb formation. Dysregulation of BOC has been linked to aberrant cell proliferation and migration, implicating its role in cancer progression and metastasis. Structurally, BOC contains multiple Ig-like domains and fibronectin type III repeats, which mediate its interactions with extracellular ligands and intracellular signaling molecules. Studies have shown that BOC modulates the balance between cell proliferation and differentiation, particularly in myogenic and neuronal contexts. It is also implicated in synaptic development and plasticity, supporting its diverse functional roles. Emerging research highlights its potential as a therapeutic target in cancers where Hedgehog signaling is dysregulated, such as basal cell carcinoma and medulloblastoma.
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