Human Boc Cell Adhesion Associated, Oncogene Regulated (BOC) Protein

Product specifications

Proteins and Peptides

Boc Cell Adhesion Associated, Oncogene Regulated (BOC)

HEK293 cells

Activity: Not tested
Sequence Fragment: Asp31-Ser157
Tag: C-terminal 6 His tag

Human

Calculated MW: 14.2 kDa  Observed MW (SDS-PAGE): 20-38 kDa

Recombinant

> 95% (SDS-PAGE)

0.2 µm filtered prior to lyophilization.

10 µg

50 µg

Lyophilized

SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80.

Shipped within 5-15 working days.

Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.

No

Q96DN7

91653

Boi,CDON2,Brother of CDO,Protein BOC

Protein BOC

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

BOC is a member of the immunoglobulin (Ig) superfamily and functions as a cell surface receptor involved in cell adhesion, axon guidance, and myogenic differentiation. It is predominantly expressed in neural and muscle tissues, where it interacts with other cell adhesion molecules and receptors to facilitate cell-cell communication and signaling. BOC plays a crucial role in the Hedgehog (Hh) signaling pathway by acting as a co-receptor for Sonic Hedgehog (Shh), enhancing its signaling and influencing developmental processes such as neural tube patterning and limb formation. Dysregulation of BOC has been linked to aberrant cell proliferation and migration, implicating its role in cancer progression and metastasis. Structurally, BOC contains multiple Ig-like domains and fibronectin type III repeats, which mediate its interactions with extracellular ligands and intracellular signaling molecules. Studies have shown that BOC modulates the balance between cell proliferation and differentiation, particularly in myogenic and neuronal contexts. It is also implicated in synaptic development and plasticity, supporting its diverse functional roles. Emerging research highlights its potential as a therapeutic target in cancers where Hedgehog signaling is dysregulated, such as basal cell carcinoma and medulloblastoma.

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