APOC4 - Apolipoprotein C4 | Elisa - Clia - Antibody - Protein

Family main features

Background:

Apolipoprotein C4 (APOC4) is a protein encoded by the APOC4 gene located on chromosome 19 in humans. It is a member of the apolipoprotein C family, which also includes APOC1, APOC2, and APOC3. APOC4 is primarily synthesized in the liver and is found associated with circulating lipoprotein particles. The exact function of APOC4 is not as well-characterized as some other members of the apolipoprotein C family, but it is believed to play a role in lipid metabolism and the regulation of lipoprotein particle properties. Like other apolipoproteins, APOC4 likely interacts with lipoprotein particles, influencing their structure, metabolism, and interactions with other molecules in the bloodstream. While the specific functions of APOC4 are still being elucidated, it is known that genetic variations in the APOC4 gene can impact lipid metabolism and cardiovascular health. Certain polymorphisms in APOC4 have been associated with alterations in plasma lipid levels and an increased risk of cardiovascular diseases, such as atherosclerosis and coronary artery disease. The expression of the APOC4 gene is regulated by various factors, including dietary nutrients, hormones, and transcriptional regulators. Factors such as peroxisome proliferator-activated receptors (PPARs), hepatocyte nuclear factor 4 alpha (HNF4α), and insulin may influence APOC4 expression levels.


Protein Structure:

  • Primary Structure: APOC4 consists of 127 amino acids.
  • Secondary Structure: It contains amphipathic alpha-helices that enable the protein to interact with lipid surfaces and lipoprotein particles.
  • Tertiary Structure: The protein adopts a conformation that allows it to bind efficiently to lipoproteins.
  • Quaternary Structure: APOC4 functions as part of lipoprotein complexes, interacting with other apolipoproteins to influence lipid metabolism.


Classification and Subtypes:

APOC4 is classified within the apolipoprotein C family, which includes APOC1, APOC2, and APOC3. These proteins share structural similarities and are involved in the regulation of lipid metabolism.


Function and Biological Significance:

  • Lipid Metabolism: APOC4 is involved in the regulation of lipid transport and metabolism. It influences the distribution and clearance of triglyceride-rich lipoproteins.
  • Modulation of Enzymes: Similar to other apolipoproteins, APOC4 likely modulates the activity of enzymes involved in lipid metabolism, such as lipoprotein lipase (LPL).
  • Lipoprotein Assembly: APOC4 may play a role in the assembly and secretion of lipoproteins from the liver.
  • Triglyceride Levels: It is implicated in the maintenance of plasma triglyceride levels and the overall lipid profile.


Interactions:

  • Lipoprotein Interactions: APOC4 is a component of chylomicrons, VLDL, and HDL. It interacts with other apolipoproteins to stabilize these particles and regulate their metabolism.
  • Enzyme Interactions: Although specific interactions with enzymes are less well-characterized than for other apolipoproteins, APOC4 is believed to influence lipid metabolism enzymes similarly.
  • Receptor Interactions: APOC4 may interact with lipoprotein receptors, affecting the uptake and clearance of lipoprotein particles.


Clinical Issues:

  • Hyperlipidemia: Variations in APOC4 levels have been associated with altered lipid profiles, potentially contributing to conditions such as hyperlipidemia.
  • Cardiovascular Disease: Given its role in lipid metabolism, abnormal levels of APOC4 may be linked to an increased risk of cardiovascular diseases, including atherosclerosis.
  • Genetic Variants: Genetic polymorphisms in the APOC4 gene can affect its function and expression, influencing an individual's lipid profile and susceptibility to lipid-related disorders.


Summary:

Apolipoprotein C4 (APOC4) is an important protein in lipid metabolism, although it is less well-studied compared to other members of the apolipoprotein C family. APOC4 contributes to the regulation of triglyceride-rich lipoproteins and overall lipid homeostasis. Its interactions with lipoproteins and potential modulation of lipid-metabolizing enzymes underline its significance in maintaining a balanced lipid profile. Variations in APOC4 levels and genetic polymorphisms can impact lipid metabolism, highlighting its clinical relevance in conditions like hyperlipidemia and cardiovascular disease. Further research is needed to fully elucidate the specific functions and mechanisms of APOC4 in lipid metabolism.



APOC4 Recommended name:

Apolipoprotein C4 (APOC3)

Aliases for APOC4

APOC4, APO-CIV, APOC-IV, apolipoprotein C4,Apolipoprotein C-IV

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, CLIA Kits, Primary Antibodies) relacionados con APOC4 - Apolipoprotein C4

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaAPOC4abx521138Cow Apolipoprotein C4 (APOC4) ELISA KitCowSerum, plasma and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ3SYR5RUO
FineTestAPOC4EH2474Human APOC4(Apolipoprotein C-IV) ELISA KithumanSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody7.813-500pg/ml96TP55056RUO
AbbexaAPOC4abx251841Human Apolipoprotein C4 (APOC4) ELISA KitHumanSerum, plasma and other biological fluids.Sandwich7.81 pg/ml - 500 pg/ml< 4.7 pg/ml61196 testsP55056RUO
AbbexaAPOC4abx493130Human Apolipoprotein C4 (APOC4) CLIA KitHumanSerum, plasma and other biological fluids.Sandwich1.56 ng/ml - 100 ng/ml< 0.64 ng/ml84596 testsRUO
AbbexaAPOC4abx195175Human Apolipoprotein C4 (ApoC4) CLIA KitHumanSerum, plasma and other biological fluids.Sandwich7.81 pg/ml - 500 pg/ml4.69 pg/ml643.596 testsRUO
AbbexaAPOC4abx150715Human Apolipoprotein C4 (APOC4) ELISA KitHumanSerum, plasma and other biological fluids.Sandwich1.56 ng/ml - 100 ng/ml< 0.64 ng/ml68996 testsRUO
FineTestAPOC4EM0845Mouse APO-C4(Apolipoprotein C4) ELISA KitmouseSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody0.313-20ng/ml96TQ61268RUO
AbbexaAPOC4abx255190Mouse Apolipoprotein C4 (APOC4) ELISA KitMouseSerum, plasma and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml61196 testsQ61268RUO
AbbexaAPOC4abx195176Mouse Apolipoprotein C4 (APOC4) CLIA KitMouseSerum, plasma and other biological fluids.62.5 pg/ml - 4000 pg/ml37.5 pg/ml643.596 testsRUO
AbbexaAPOC4abx362349Rabbit Apolipoprotein C4 (APOC4) ELISA KitRabbitSerum, plasma and other biological fluids.Sandwich0.312 pg/ml - 20 pg/ml0.19 pg/ml62496 testsRUO
AbbexaAPOC4abx521141Rat Apolipoprotein C4 (APOC4) ELISA KitRatSerum, plasma and other biological fluids.15.6 pg/ml - 1000 pg/ml71596 testsP55797RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestAPOC4FNab00498anti- APOC4 antibodyhumanpolyclonalRabbitapolipoprotein C-IVIgGUnconjugatedELISA, WB, IF100µgP55056RUO
AbbexaAPOC4abx230498Apolipoprotein C4 (APOC4) AntibodyHumanPolyclonalRabbitApolipoprotein C4 (APOC4)IgGUnconjugatedELISA, WB, IF/ICC364100 µgP55056RUO
AbbexaAPOC4abx339178Apolipoprotein C4 (APOC4) AntibodyHumanPolyclonalRabbitApolipoprotein C4 (APOC4)IgGUnconjugatedELISA, IHC26050 µlP55056RUO
AbbexaAPOC4abx339258Apolipoprotein C4 (APOC4) AntibodyHumanPolyclonalRabbitApolipoprotein C4 (APOC4)IgGUnconjugatedELISA, IHC26050 µlP55056RUO
AbbexaAPOC4abx175438Apolipoprotein C4 (APOC4) AntibodyMousePolyclonalRabbitApolipoprotein C4 (APOC4)UnconjugatedWB, IHC, IF/ICC273100 µlRUO
AbbexaAPOC4abx129568Apolipoprotein C4 (APOC4) AntibodyMousePolyclonalRabbitApolipoprotein C4 (APOC4)UnconjugatedWB, IHC, IF/ICC273100 µlRUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaAPOC4abx168336Mouse Apolipoprotein C4 (APOC4) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE22110 µgRUO
AbbexaAPOC4abx651854Mouse Apolipoprotein C4 (APOC4) Peptide (OVA)MouseSyntheticOVAWB, SDS-PAGE494100 µgQ61268RUO
AbbexaAPOC4abx652553Human Apolipoprotein C4 (APOC4) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE20810 µgP55056RUO

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