Apolipoprotein C4 (APOC4) Antibody
273€ (100 µl)
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Name
Apolipoprotein C4 (APOC4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx175438
Tested Applications
WB, IHC, IF/ICC
Description
Apolipoprotein C4 (APOC4) Antibody is a Rabbit Polyclonal antibody against Apolipoprotein C4 (APOC4).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apolipoprotein C4 (APOC4) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | APOC4, APO-CIV, APOC-IV, apolipoprotein C4,Apolipoprotein C-IV |
| Background | Antibody anti-APOC4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
APOC4 is a lesser-known member of the apolipoprotein C family, encoded within the APOC2-APOC4-APOC3 gene cluster on chromosome 19. It is primarily synthesized in the liver and is associated with VLDL and chylomicrons, suggesting a role in triglyceride metabolism and lipoprotein regulation. Although the exact function of APOC4 is not fully characterized, studies suggest it may modulate the activity of lipoprotein lipase (LPL) and influence triglyceride hydrolysis and clearance. Variants in the APOC4 gene have been linked to elevated plasma triglyceride levels and increased susceptibility to atherosclerosis and metabolic disorders. APOC4 is co-regulated with APOC2 and APOC3, indicating a cooperative role in lipoprotein metabolism and lipid homeostasis. Its physiological significance is under investigation, but its presence in triglyceride-rich lipoproteins highlights its potential contribution to lipid transport and cardiovascular risk. Further research is needed to elucidate the precise biological role of APOC4 and its therapeutic relevance in lipid-related disorders.
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