Family main features
Aldo-keto reductase family 1 member A1 (AKR1A1), also known as aldose reductase, is an enzyme that belongs to the aldo-keto reductase superfamily. This enzyme catalyzes the reduction of a variety of aldehydes and ketones, using NADPH as a cofactor, to produce corresponding alcohols.One of the well-known substrates of AKR1A1 is glucose. In particular, AKR1A1 catalyzes the conversion of glucose to sorbitol, which is an intermediate in the polyol pathway. This pathway is implicated in the pathogenesis of diabetic complications, as excessive sorbitol accumulation can lead to cellular damage and dysfunction, particularly in tissues that do not require insulin for glucose uptake, such as the lens of the eye and peripheral nerves. AKR1A1 is expressed in various tissues throughout the body, including the liver, kidney, lens, and peripheral nerves. Its expression and activity are regulated by various factors, including glucose levels and oxidative stress.
Aldo-keto reductase family 1 member A1 (AKR1A1) is a versatile enzyme involved in the reduction of aldehydes and ketones, playing crucial roles in detoxification, drug metabolism, and carbohydrate and hormone metabolism. With a conserved structure typical of the aldo-keto reductase family, AKR1A1 interacts with NADP(H) to carry out its functions. It has significant clinical implications, including roles in diabetic complications, cancer progression, cardiovascular diseases, and drug resistance, making it an important target for therapeutic intervention and clinical research.
Aldo-keto reductase family 1 member A1(AKR1A1)
AKR1A1, ALDR1, ALR,ARM, DD3
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con AKR1A - Aldo-keto reductase family 1 member A
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Esta página contiene 21 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | AKR1A1 | abx385689 | Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | P14550 | RUO |
Abbexa | AKR1A1 | abx501371 | Mouse Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.39 ng/ml - 25 ng/ml | < 0.17 ng/ml | 687.5 | 96 tests | Q9JII6 | RUO |
Abbexa | AKR1A1 | abx501373 | Rat Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.34 ng/ml | 687.5 | 96 tests | P51635 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | AKR1A1 | FNab00260 | anti- AKR1A1 antibody | human | polyclonal | Rabbit | aldo-keto reductase family 1, member A1 (aldehyde reductase) | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | P14550 | RUO | |
Abbexa | AKR1A1 | abx314745 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Biotin | ELISA | 162.5 | 20 µg | P14550 | RUO | |
Abbexa | AKR1A1 | abx025100 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P14550 | RUO | |
Abbexa | AKR1A1 | abx314743 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody (HRP) | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | HRP | ELISA | 162.5 | 20 µg | P14550 | RUO | |
Abbexa | AKR1A1 | abx314744 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody (FITC) | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | FITC | 162.5 | 20 µg | P14550 | RUO | ||
Abbexa | AKR1A1 | abx038224 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | AKR1A1 | abx317947 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | P14550 | RUO | |
Abbexa | AKR1A1 | abx327779 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P14550 | RUO | |
Abbexa | AKR1A1 | abx000991 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | WB, IHC | 175 | 20 µl | P14550 | RUO | |
Abbexa | AKR1A1 | abx241948 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P14550 | RUO | |
Abbexa | AKR1A1 | abx110925 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | P14550 | RUO | |
Abbexa | AKR1A1 | abx242190 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P14550 | RUO | |
Abbexa | AKR1A1 | abx014163 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB | 43.75 | 10 µg | P14550 | RUO | |
Abbexa | AKR1A1 | abx230260 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | P14550 | RUO | |
Abbexa | AKR1A1 | abx038473 | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody | Human | Polyclonal | Rabbit | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | AKR1A1 | P4762 | Recombinant Human AKR1A1 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P14550 | RUO | ||
Abbexa | AKR1A1 | abx693348 | Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Protein | Human | Recombinant | E. coli | SDS-PAGE | 837.5 | 100 µg | P14550 | RUO | |
Abbexa | AKR1A1 | abx073091 | Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Protein | Human | Recombinant | E. coli | SDS-PAGE | 225 | 5 µg | P14550 | RUO |
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