AKR1A1 antibody
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Description
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldo-keto reductase family 1, member A1 (aldehyde reductase) (AKR1A1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 37 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P14550 |
| Gene ID | 10327 |
| Alias | AKR1A1, ALDR1, ALR,ARM, DD3 |
| Background | Antibody anti-AKR1A1 |
| Status | RUO |
| Note | Mol. Weight 37 kDa |
Descripción
AKR1A1 is a widely expressed enzyme that belongs to the aldo-keto reductase superfamily. It catalyzes the reduction of aldehydes and ketones to their respective alcohols using NADPH as a cofactor, playing a key role in detoxifying reactive aldehydes generated during lipid peroxidation and metabolism. AKR1A1 is involved in the metabolism of endogenous compounds, such as prostaglandins, steroids, and lipid-derived aldehydes, as well as exogenous toxins, including chemotherapeutics and environmental pollutants. AKR1A1 has significant antioxidant properties due to its ability to reduce harmful aldehydes, thus protecting cells from oxidative stress. It also contributes to glucose metabolism by participating in the sorbitol pathway, particularly in the liver, kidneys, and lens. Dysregulation of AKR1A1 is implicated in metabolic disorders, including diabetic complications, cataract formation, and cardiovascular diseases. Additionally, AKR1A1 has been shown to play a role in drug resistance by metabolizing chemotherapeutic agents, making it a target for improving cancer treatments.
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein.
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Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody is a Rabbit Polyclonal antibody against Aldo-Keto Reductase Family 1 Member A1 (AKR1A1). This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011].
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