Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Protein
234€ (5 µg)
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Name
Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073091
Tested Applications
SDS-PAGE
Description
Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) is a recombinant protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) |
| Host | E. coli |
| Reactivity | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: 1-325 AA. |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Observed MW | 36.5 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl, pH 8.0, containing 50 mM NaCl and 10% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at or below -18°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14550 |
| Alias | AKR1A1, ALDR1, ALR,ARM, DD3 |
| Background | Protein AKR1A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Concentration: 1 mg/ml |
Background
AKR1A1 is a widely expressed enzyme that belongs to the aldo-keto reductase superfamily. It catalyzes the reduction of aldehydes and ketones to their respective alcohols using NADPH as a cofactor, playing a key role in detoxifying reactive aldehydes generated during lipid peroxidation and metabolism. AKR1A1 is involved in the metabolism of endogenous compounds, such as prostaglandins, steroids, and lipid-derived aldehydes, as well as exogenous toxins, including chemotherapeutics and environmental pollutants. AKR1A1 has significant antioxidant properties due to its ability to reduce harmful aldehydes, thus protecting cells from oxidative stress. It also contributes to glucose metabolism by participating in the sorbitol pathway, particularly in the liver, kidneys, and lens. Dysregulation of AKR1A1 is implicated in metabolic disorders, including diabetic complications, cataract formation, and cardiovascular diseases. Additionally, AKR1A1 has been shown to play a role in drug resistance by metabolizing chemotherapeutic agents, making it a target for improving cancer treatments.
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