Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Protein
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Description
Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) is a recombinant protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) |
| Host | E. coli |
| Reactivity | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Observed MW | Molecular Weight: 36.5 kDa Concentration: 1 mg/ml Sequence Fragment: 1-325 AA. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl, pH 8.0, containing 50 mM NaCl and 10% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at or below -18 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14550 |
| Alias | AKR1A1, ALDR1, ALR,ARM, DD3 |
| Background | Protein AKR1A1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AKR1A1 is a widely expressed enzyme that belongs to the aldo-keto reductase superfamily. It catalyzes the reduction of aldehydes and ketones to their respective alcohols using NADPH as a cofactor, playing a key role in detoxifying reactive aldehydes generated during lipid peroxidation and metabolism. AKR1A1 is involved in the metabolism of endogenous compounds, such as prostaglandins, steroids, and lipid-derived aldehydes, as well as exogenous toxins, including chemotherapeutics and environmental pollutants. AKR1A1 has significant antioxidant properties due to its ability to reduce harmful aldehydes, thus protecting cells from oxidative stress. It also contributes to glucose metabolism by participating in the sorbitol pathway, particularly in the liver, kidneys, and lens. Dysregulation of AKR1A1 is implicated in metabolic disorders, including diabetic complications, cataract formation, and cardiovascular diseases. Additionally, AKR1A1 has been shown to play a role in drug resistance by metabolizing chemotherapeutic agents, making it a target for improving cancer treatments.
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Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody is a Rabbit Polyclonal antibody against Aldo-Keto Reductase Family 1 Member A1 (AKR1A1). This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011].
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