Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody (HRP)
169€ (20 µg)
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Name
Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx314743
Tested Applications
ELISA
Description
Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody (HRP) is a Rabbit Polyclonal against Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Immunogen: Recombinant Human Alcohol dehydrogenase [NADP (+)] protein (2-325AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14550 |
| Gene ID | 10327 |
| OMIM | 103830 |
| Alias | AKR1A1, ALDR1, ALR,ARM, DD3 |
| Background | Antibody anti-AKR1A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKR1A1 is a widely expressed enzyme that belongs to the aldo-keto reductase superfamily. It catalyzes the reduction of aldehydes and ketones to their respective alcohols using NADPH as a cofactor, playing a key role in detoxifying reactive aldehydes generated during lipid peroxidation and metabolism. AKR1A1 is involved in the metabolism of endogenous compounds, such as prostaglandins, steroids, and lipid-derived aldehydes, as well as exogenous toxins, including chemotherapeutics and environmental pollutants. AKR1A1 has significant antioxidant properties due to its ability to reduce harmful aldehydes, thus protecting cells from oxidative stress. It also contributes to glucose metabolism by participating in the sorbitol pathway, particularly in the liver, kidneys, and lens. Dysregulation of AKR1A1 is implicated in metabolic disorders, including diabetic complications, cataract formation, and cardiovascular diseases. Additionally, AKR1A1 has been shown to play a role in drug resistance by metabolizing chemotherapeutic agents, making it a target for improving cancer treatments.
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