Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody

Este producto es parte de AKR1A - Aldo-keto reductase family 1 member A
Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Antibody

Pida mas información

935106861

info@markelab.com

Precio

281.25€ (80 µl)

Antibody anti-AKR1A1

proveedor

Abbexa

reference

abx025100

Tested Applications

ELISA, WB, IHC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.


Background

AKR1A1 is a widely expressed enzyme that belongs to the aldo-keto reductase superfamily. It catalyzes the reduction of aldehydes and ketones to their respective alcohols using NADPH as a cofactor, playing a key role in detoxifying reactive aldehydes generated during lipid peroxidation and metabolism. AKR1A1 is involved in the metabolism of endogenous compounds, such as prostaglandins, steroids, and lipid-derived aldehydes, as well as exogenous toxins, including chemotherapeutics and environmental pollutants. AKR1A1 has significant antioxidant properties due to its ability to reduce harmful aldehydes, thus protecting cells from oxidative stress. It also contributes to glucose metabolism by participating in the sorbitol pathway, particularly in the liver, kidneys, and lens. Dysregulation of AKR1A1 is implicated in metabolic disorders, including diabetic complications, cataract formation, and cardiovascular diseases. Additionally, AKR1A1 has been shown to play a role in drug resistance by metabolizing chemotherapeutic agents, making it a target for improving cancer treatments.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Aldo-Keto Reductase Family 1 Member A1 (AKR1A1)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC


purification

Purified Rabbit Polyclonal Antibody.


buffer

PBS containing 0.09% sodium azide.


size 1

80 µl


size 2

400 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

AKR1A1


dry ice

No


availability

Shipped within 5-10 working days.


alias

AKR1A1, ALDR1, ALR,ARM, DD3


note

This product is for research use only.


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