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Acrosin (ACR) is a serine protease enzyme predominantly found in the acrosome of sperm cells. It plays a critical role in fertilization by facilitating the penetration of the sperm through the zona pellucida, the outer glycoprotein layer of the oocyte. Acrosin plays a significant role in the penetration of the protective layers surrounding the egg during fertilization.Its primary function is to help the sperm penetrate the zona pellucida, a glycoprotein layer surrounding the egg cell, by digesting the proteins in this layer. Acrosin is initially synthesized in an inactive form called proacrosin. Upon reaching the vicinity of the egg, proacrosin is activated by a process involving calcium ions and pH changes, converting it into active acrosin.After activation, acrosin helps the sperm cell to penetrate the zona pellucida, enabling it to reach and fertilize the egg. This process is crucial for successful fertilization and subsequent embryo development. Dysregulation of acrosin activity can lead to impaired sperm function and fertility issues.Acrosin has been a subject of research in the field of reproductive biology and fertility.
Acrosin is synthesized as an inactive zymogen called proacrosin. Upon activation, proacrosin is converted to active acrosin, which has the following structural features:
Acrosin does not have multiple subtypes but exists in different forms based on its activation state:
Acrosin plays several key roles in the fertilization process:
Acrosin interacts with various molecules and structures involved in fertilization:
Dysfunction or deficiency in acrosin activity can lead to fertility issues:
Acrosin (ACR) is a serine protease enzyme essential for the fertilization process. Synthesized as the inactive zymogen proacrosin, it is activated to acrosin, which hydrolyzes zona pellucida glycoproteins, enabling sperm to penetrate the oocyte’s protective layer. Acrosin’s critical roles include facilitating sperm-oocyte interaction and participating in the acrosome reaction. Interactions with zona pellucida glycoproteins, other acrosomal enzymes, and the oocyte plasma membrane are essential for its function. Dysregulation of acrosin activity can lead to male infertility and fertilization failures, making it a valuable diagnostic marker for assessing sperm function.
Acrosin(ACR)
SPGF87
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | ACR | EH2014 | Human ACR(Acrosin) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 6.25-400mIU/ml | 96T | P10323 | RUO | ||
Abbexa | ACR | abx493282 | Human Acrosin (ACR) CLIA Kit | Human | Sperm. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.062 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ACR | abx570414 | Human Acrosin (ACR) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 6.25 U/L - 400 U/L | 562.5 | 96 tests | P10323 | RUO | |
Abbexa | ACR | abx150528 | Human Acrosin (ACR) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | ACR | abx518912 | Mouse Acrosin (ACR) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P23578 | RUO | |
Abbexa | ACR | abx518913 | Pig Acrosin (ACR) ELISA Kit | Pig | Serum,Plasma,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P08001 | RUO | ||
Abbexa | ACR | abx496465 | Rat Acrosin (ACR) CLIA Kit | Rat | Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.061 ng/ml | 812.5 | 96 tests | P29293 | RUO |
Abbexa | ACR | abx258769 | Rat Acrosin (ACR) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 618.75 | 96 tests | P29293 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACR | abx432274 | Acrosin heavy chain Antibody | Polyclonal | Goat | Acrosin heavy chain | Unconjugated | P-ELISA | 250 | 200 µl | RUO | |||
Abbexa | ACR | abx034218 | Acrosin (ACR) Antibody | Human | Polyclonal | Rabbit | Acrosin (ACR) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | P10323 | RUO | |
Abbexa | ACR | abx324087 | Acrosin (ACR) Antibody | Human | Polyclonal | Rabbit | Acrosin (ACR) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P10323 | RUO | |
Abbexa | ACR | abx375040 | Acrosin (ACR) Antibody | Human | Polyclonal | Rabbit | Acrosin (ACR) | Unconjugated | ELISA, WB | 337.5 | 100 µg | P10323 | RUO | |
Abbexa | ACR | abx432275 | Acrosin light chain Antibody | Human | Polyclonal | Goat | Acrosin light chain | Unconjugated | P-ELISA, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | ACR | abx339445 | Acrosin (ACR) Antibody | Human | Polyclonal | Rabbit | Acrosin (ACR) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P10323 | RUO | |
Abbexa | ACR | abx339645 | Acrosin (ACR) Antibody | Human | Polyclonal | Rabbit | Acrosin (ACR) | Unconjugated | ELISA, WB | 250 | 50 µl | P10323 | RUO | |
Abbexa | ACR | abx175219 | Acrosin (ACR) Antibody | Mouse | Polyclonal | Rabbit | Acrosin (ACR) | Unconjugated | WB, IHC, IF/ICC | 725 | 1 ml | RUO | ||
Abbexa | ACR | abx140166 | Acrosin (ACR) Antibody | Pig | Monoclonal | Mouse | Acrosin (ACR) | Unconjugated | WB, IF/ICC, FCM | 325 | 0.1 mg | P08001 | RUO | |
Abbexa | ACR | abx100066 | Acrosin (ACR) Antibody | Rat | Polyclonal | Rabbit | Acrosin (ACR) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P29293 | RUO | |
Abbexa | ACR | abx370743 | Acrosin (ACR) Antibody Pair | Rat | Acrosin (ACR) | ELISA | 1462.5 | 5 × 96 tests | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACR | abx652371 | Mouse Acrosin (ACR) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO | |
Abbexa | ACR | abx652370 | Human Acrosin (ACR) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | ACR | abx065106 | Rat Acrosin (ACR) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P29293 | RUO |
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