Acrosin (ACR) Antibody

Este producto es parte de ACR - Acrosin
Product Graph
221€ (50 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Acrosin (ACR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324087
tested applications
ELISA, WB

Description

ACR Antibody is a Rabbit Polyclonal against ACR.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

CategoryPrimary Antibodies
Immunogen TargetAcrosin (ACR)
HostRabbit
ReactivityHuman
Recommended DilutionELISA: 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified by affinity chromatography.
Size 150 µg
Size 2100 µg
FormLiquid
Tested ApplicationsELISA, WB
BufferPBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP10323
Gene ID49
AliasSPGF87
BackgroundAntibody anti-ACR
StatusRUO

Acrosin (ACR) is a serine protease enzyme localized in the acrosome of spermatozoa, where it plays a critical role in the fertilization process. It is synthesized as an inactive zymogen called proacrosin, which is activated during the acrosome reaction to assist in the penetration of the sperm through the zona pellucida, the outer glycoprotein layer of the oocyte. Acrosin functions by hydrolyzing zona pellucida proteins and facilitating sperm binding to the egg, making it essential for successful fertilization. The activity of acrosin is tightly regulated to prevent premature activation, ensuring that it is only active during the fertilization process. Dysregulation or mutations affecting acrosin function have been associated with male infertility due to impaired sperm-oocyte interaction. Acrosin is also studied as a marker for sperm acrosomal integrity and functionality in reproductive biology and clinical diagnostics. Research into acrosin inhibitors is being explored as a potential strategy for developing non-hormonal contraceptives.

Related Products

EH2014

Human ACR(Acrosin) ELISA Kit

Ver Producto
abx034218

Acrosin (ACR) Antibody

ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.

Ver Producto
abx065106

Rat Acrosin (ACR) Protein

Recombinant Acrosin (ACR) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).

Ver Producto