Acrosin (ACR) Antibody
338€ (0.1 mg)
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Name
Acrosin (ACR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140166
Tested Applications
WB, IF/ICC, FCM
Description
Acrosin Antibody is a Mouse Monoclonal against Acrosin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acrosin (ACR) Immunogen: Acid extracts of boar spermatozoa were subjected to hydrophobic chromatography and the pooled fraction with reactivity to N-alpha benzoylarginine-4-nitroanilide was used for immunization. |
| Host | Mouse |
| Reactivity | Pig |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | FCM: 1-12 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | V909 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IF/ICC, FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P08001 |
| Gene ID | 397098 |
| Alias | SPGF87 |
| Background | Antibody anti-ACR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Acrosin (ACR) is a serine protease enzyme localized in the acrosome of spermatozoa, where it plays a critical role in the fertilization process. It is synthesized as an inactive zymogen called proacrosin, which is activated during the acrosome reaction to assist in the penetration of the sperm through the zona pellucida, the outer glycoprotein layer of the oocyte. Acrosin functions by hydrolyzing zona pellucida proteins and facilitating sperm binding to the egg, making it essential for successful fertilization. The activity of acrosin is tightly regulated to prevent premature activation, ensuring that it is only active during the fertilization process. Dysregulation or mutations affecting acrosin function have been associated with male infertility due to impaired sperm-oocyte interaction. Acrosin is also studied as a marker for sperm acrosomal integrity and functionality in reproductive biology and clinical diagnostics. Research into acrosin inhibitors is being explored as a potential strategy for developing non-hormonal contraceptives.
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