Transcription Factor AP-2 Epsilon (TFAP2E) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Transcription Factor AP-2 Epsilon (TFAP2E) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx238620
tested applications
ELISA, WB
Description
TFAP2E Antibody is a Rabbit Polyclonal against TFAP2E.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transcription Factor AP-2 Epsilon (TFAP2E) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6VUC0 |
| Gene ID | 339488 |
| OMIM | 614428 |
| Alias | AP-2epsilon,AP2E,Activating enhancer-binding protein 2-epsilon |
| Background | Antibody anti-TFAP2E |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
TFAP2E is a member of the AP-2 family that regulates gene transcription during embryogenesis, tissue differentiation, and organ development. TFAP2E is expressed in various epithelial and neural tissues during development, where it controls cell proliferation, survival, and differentiation by modulating target genes involved in cell adhesion, apoptosis, and morphogenesis. It has also been implicated in the regulation of neural crest migration, contributing to craniofacial and limb development. In cancer biology, altered TFAP2E expression is associated with tumor progression, particularly in colorectal and gastric cancers, where it regulates Wnt/β-catenin signaling and chemoresistance. Knockout studies reveal developmental abnormalities in neural and epithelial tissues, underscoring its role in transcriptional regulation, tissue-specific gene expression, and developmental homeostasis.
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