TFAP2E antibody

Este producto es parte de TFAP2 - Transcription factor AP-2 alpha
Product Graph
Contáctenos para saber el precio

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
TFAP2E antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08620
tested applications
ELISA, WB

Description

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation(By similarity).

Documents del producto

Instrucciones
Descargar
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
transcription factor AP-2 epsilon(activating enhancer binding protein 2 epsilon) (TFAP2E)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
46 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q6VUC0
Gene ID
339488
Alias
AP-2epsilon,AP2E,Activating enhancer-binding protein 2-epsilon
Background
Antibody anti-TFAP2E
Status
RUO
Note
Mol. Weight 46 kDa

Descripción

TFAP2E is a member of the AP-2 family that regulates gene transcription during embryogenesis, tissue differentiation, and organ development. TFAP2E is expressed in various epithelial and neural tissues during development, where it controls cell proliferation, survival, and differentiation by modulating target genes involved in cell adhesion, apoptosis, and morphogenesis. It has also been implicated in the regulation of neural crest migration, contributing to craniofacial and limb development. In cancer biology, altered TFAP2E expression is associated with tumor progression, particularly in colorectal and gastric cancers, where it regulates Wnt/β-catenin signaling and chemoresistance. Knockout studies reveal developmental abnormalities in neural and epithelial tissues, underscoring its role in transcriptional regulation, tissue-specific gene expression, and developmental homeostasis.

Related Products

FNab08620

TFAP2E antibody

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation(By similarity).

Ver Producto
P1559

Recombinant Human TFAP2E

Ver Producto
abx238620

Transcription Factor AP-2 Epsilon (TFAP2E) Antibody

TFAP2E Antibody is a Rabbit Polyclonal against TFAP2E.

Ver Producto