Recombinant Human TFAP2E

Background

TFAP2E is a member of the AP-2 family that regulates gene transcription during embryogenesis, tissue differentiation, and organ development. TFAP2E is expressed in various epithelial and neural tissues during development, where it controls cell proliferation, survival, and differentiation by modulating target genes involved in cell adhesion, apoptosis, and morphogenesis. It has also been implicated in the regulation of neural crest migration, contributing to craniofacial and limb development. In cancer biology, altered TFAP2E expression is associated with tumor progression, particularly in colorectal and gastric cancers, where it regulates Wnt/β-catenin signaling and chemoresistance. Knockout studies reveal developmental abnormalities in neural and epithelial tissues, underscoring its role in transcriptional regulation, tissue-specific gene expression, and developmental homeostasis.