Transcription Factor AP-2-Delta (TFAP2D) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Transcription Factor AP-2-Delta (TFAP2D) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029880
tested applications
ELISA, WB, IF/ICC
Description
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transcription Factor AP-2-Delta (TFAP2D) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7Z6R9 |
| Alias | AP-2delta,TFAP2BL1,Activating enhancer-binding protein 2-delta,Transcription factor AP-2-beta-like 1 |
| Background | Antibody anti-TFAP2D |
| Status | RUO |
Descripción
TFAP2D is a lesser-characterized member of the AP-2 transcription factor family, primarily involved in the regulation of gene expression during development and differentiation. It binds to target DNA sequences in regulatory regions to control genes involved in neural crest cell formation, epithelial tissue differentiation, and organogenesis. TFAP2D is expressed in embryonic tissues, where it plays a role in cell cycle regulation, apoptosis, and tissue morphogenesis. Its function overlaps with other AP-2 family members, although its specific biological roles remain under investigation. Dysregulation of TFAP2D may contribute to developmental abnormalities and potentially tumorigenesis. Knockdown or loss-of-function studies suggest that TFAP2D is required for proper embryonic patterning, epithelial cell development, and transcriptional control during organ development.
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