Secretin Receptor (SCTR) Antibody
195€ (50 µg)
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935106861
info@markelab.com
name
Secretin Receptor (SCTR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324874
tested applications
ELISA, WB, IHC, IF/ICC
Description
SCTR Antibody is a Rabbit Polyclonal against SCTR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Secretin Receptor (SCTR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P47872 |
| Gene ID | 6344 |
| Alias | SCTR,SCT-R,SR |
| Background | Antibody anti-SCTR |
| Status | RUO |
Descripción
Secretin receptor (SCTR) is a G protein-coupled receptor (GPCR) activated by secretin, a peptide hormone that regulates water and bicarbonate secretion in the pancreas and gastrointestinal tract. SCTR is expressed primarily in the pancreas, small intestine, liver, and central nervous system. Upon activation, SCTR stimulates adenylyl cyclase, increasing cyclic AMP (cAMP) and activating protein kinase A (PKA), which drives bicarbonate secretion from pancreatic ductal cells, aiding in neutralizing gastric acid. SCTR also regulates gastric motility, bile secretion, and insulin release under certain metabolic states. Dysregulation of SCTR signaling has been implicated in pancreatic diseases, including chronic pancreatitis and pancreatic cancer, where altered secretin responses disrupt homeostasis. In the brain, SCTR plays a role in neuroprotection, learning, and mood regulation, with potential relevance to cognitive and emotional disorders. Targeting SCTR signaling is being explored for therapeutic applications in pancreatic diseases, gastrointestinal disorders, and metabolic regulation.
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