anti- Secretin receptor antibody
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935106861
info@markelab.com
name
anti- Secretin receptor antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07697
tested applications
ELISA, WB
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | secretin receptor |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50-55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P47872 |
| Alias | SCTR,SCT-R,SR |
| Background | Antibody anti-SCTR |
| Status | RUO |
| Note | This product is for research use only. |
Secretin receptor (SCTR) is a G protein-coupled receptor (GPCR) activated by secretin, a peptide hormone that regulates water and bicarbonate secretion in the pancreas and gastrointestinal tract. SCTR is expressed primarily in the pancreas, small intestine, liver, and central nervous system. Upon activation, SCTR stimulates adenylyl cyclase, increasing cyclic AMP (cAMP) and activating protein kinase A (PKA), which drives bicarbonate secretion from pancreatic ductal cells, aiding in neutralizing gastric acid. SCTR also regulates gastric motility, bile secretion, and insulin release under certain metabolic states. Dysregulation of SCTR signaling has been implicated in pancreatic diseases, including chronic pancreatitis and pancreatic cancer, where altered secretin responses disrupt homeostasis. In the brain, SCTR plays a role in neuroprotection, learning, and mood regulation, with potential relevance to cognitive and emotional disorders. Targeting SCTR signaling is being explored for therapeutic applications in pancreatic diseases, gastrointestinal disorders, and metabolic regulation.
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