Secretin Receptor (SCTR) Antibody

Background

Secretin receptor (SCTR) is a G protein-coupled receptor (GPCR) activated by secretin, a peptide hormone that regulates water and bicarbonate secretion in the pancreas and gastrointestinal tract. SCTR is expressed primarily in the pancreas, small intestine, liver, and central nervous system. Upon activation, SCTR stimulates adenylyl cyclase, increasing cyclic AMP (cAMP) and activating protein kinase A (PKA), which drives bicarbonate secretion from pancreatic ductal cells, aiding in neutralizing gastric acid. SCTR also regulates gastric motility, bile secretion, and insulin release under certain metabolic states. Dysregulation of SCTR signaling has been implicated in pancreatic diseases, including chronic pancreatitis and pancreatic cancer, where altered secretin responses disrupt homeostasis. In the brain, SCTR plays a role in neuroprotection, learning, and mood regulation, with potential relevance to cognitive and emotional disorders. Targeting SCTR signaling is being explored for therapeutic applications in pancreatic diseases, gastrointestinal disorders, and metabolic regulation.