Rat Insulin Receptor Substrate 3 (IRS3) Protein

Este producto es parte de IRS -Insulin receptor substrate
Rat Insulin Receptor Substrate 3 (IRS3) Protein

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935106861

info@markelab.com

Precio

234€ (10 µg)

Protein IRS3

proveedor

Abbexa

reference

abx168504

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Insulin Receptor Substrate 3 (IRS3) Protein is a recombinant Rat protein expressed in E. coli.


Background

Insulin receptor substrate 3 (IRS3) is part of the IRS family of proteins that play a crucial role in the signaling pathways of insulin and insulin-like growth factors. Acting as a molecular scaffold, IRS3 binds to the activated insulin receptor, undergoing phosphorylation on specific tyrosine residues. This process enables the recruitment of downstream signaling molecules, such as phosphatidylinositol 3-kinase (PI3K) and Grb2, which are involved in metabolic regulation, cellular growth, and survival. IRS3 expression is primarily observed in adipose tissue and liver, suggesting its importance in glucose homeostasis and lipid metabolism. Dysregulation of IRS3 activity has been implicated in conditions such as insulin resistance, obesity, and type 2 diabetes. Research on IRS3 has highlighted its potential as a therapeutic target for enhancing insulin sensitivity in metabolic disorders.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Insulin Receptor Substrate 3 (IRS3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 15.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ser110 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IRS3


dry ice

No


availability

Shipped within 5-7 working days.


alias

IRS3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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