Insulin Receptor Substrate 3 (IRS3) Antibody
312€ (100 µl)
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935106861
info@markelab.com
name
Insulin Receptor Substrate 3 (IRS3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130421
tested applications
WB, IHC, IF/ICC
Description
Insulin Receptor Substrate 3 (IRS3) Antibody is a Rabbit Polyclonal against Insulin Receptor Substrate 3 (IRS3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Insulin Receptor Substrate 3 (IRS3) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | B1WBQ1 |
| Alias | IRS3 |
| Background | Antibody anti-IRS3 |
| Status | RUO |
Descripción
Insulin receptor substrate 3 (IRS3) is part of the IRS family of proteins that play a crucial role in the signaling pathways of insulin and insulin-like growth factors. Acting as a molecular scaffold, IRS3 binds to the activated insulin receptor, undergoing phosphorylation on specific tyrosine residues. This process enables the recruitment of downstream signaling molecules, such as phosphatidylinositol 3-kinase (PI3K) and Grb2, which are involved in metabolic regulation, cellular growth, and survival. IRS3 expression is primarily observed in adipose tissue and liver, suggesting its importance in glucose homeostasis and lipid metabolism. Dysregulation of IRS3 activity has been implicated in conditions such as insulin resistance, obesity, and type 2 diabetes. Research on IRS3 has highlighted its potential as a therapeutic target for enhancing insulin sensitivity in metabolic disorders.
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