Insulin Receptor Substrate 3 (IRS3) Antibody
312€ (100 µl)
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Name
Insulin Receptor Substrate 3 (IRS3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx130421
Description
Insulin Receptor Substrate 3 (IRS3) Antibody is a Rabbit Polyclonal against Insulin Receptor Substrate 3 (IRS3).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Insulin Receptor Substrate 3 (IRS3) Immunogen: IRS3 (Met1-Ser110) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | B1WBQ1 |
| Alias | IRS3 |
| Background | Antibody anti-IRS3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Insulin receptor substrate 3 (IRS3) is part of the IRS family of proteins that play a crucial role in the signaling pathways of insulin and insulin-like growth factors. Acting as a molecular scaffold, IRS3 binds to the activated insulin receptor, undergoing phosphorylation on specific tyrosine residues. This process enables the recruitment of downstream signaling molecules, such as phosphatidylinositol 3-kinase (PI3K) and Grb2, which are involved in metabolic regulation, cellular growth, and survival. IRS3 expression is primarily observed in adipose tissue and liver, suggesting its importance in glucose homeostasis and lipid metabolism. Dysregulation of IRS3 activity has been implicated in conditions such as insulin resistance, obesity, and type 2 diabetes. Research on IRS3 has highlighted its potential as a therapeutic target for enhancing insulin sensitivity in metabolic disorders.
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