Rat Insulin Receptor Substrate 3 (IRS3) CLIA Kit
903.5€ (96 tests)
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name
Rat Insulin Receptor Substrate 3 (IRS3) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx496262
tested applications
CLIA
Description
Rat Insulin Receptor Substrate 3 (IRS3) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Insulin Receptor Substrate 3 (IRS3) |
| Reactivity | Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.625 ng/ml - 40 ng/ml |
| Sensitivity | < 0.227 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IRS3 |
| Background | CLIA Kits IRS3 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Insulin receptor substrate 3 (IRS3) is part of the IRS family of proteins that play a crucial role in the signaling pathways of insulin and insulin-like growth factors. Acting as a molecular scaffold, IRS3 binds to the activated insulin receptor, undergoing phosphorylation on specific tyrosine residues. This process enables the recruitment of downstream signaling molecules, such as phosphatidylinositol 3-kinase (PI3K) and Grb2, which are involved in metabolic regulation, cellular growth, and survival. IRS3 expression is primarily observed in adipose tissue and liver, suggesting its importance in glucose homeostasis and lipid metabolism. Dysregulation of IRS3 activity has been implicated in conditions such as insulin resistance, obesity, and type 2 diabetes. Research on IRS3 has highlighted its potential as a therapeutic target for enhancing insulin sensitivity in metabolic disorders.
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