Prokineticin Receptor 1 (PROKR1) Antibody
169€ (20 µg)
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935106861
info@markelab.com
name
Prokineticin Receptor 1 (PROKR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx304959
tested applications
ELISA, IHC
Description
PROKR1 Antibody is a Rabbit Polyclonal against PROKR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Prokineticin Receptor 1 (PROKR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TCW9 |
| Gene ID | 10887 |
| OMIM | 607122 |
| Alias | PROKR1,GPR73a,VEGFR-1,ZAQ ,GPR73,G-protein coupled receptor ZAQ,G protein-coupled receptor 73 |
| Background | Antibody anti-PROKR1 |
| Status | RUO |
Descripción
PROKR1 is a G protein-coupled receptor activated by prokineticins, small peptide hormones involved in angiogenesis, inflammation, and tissue homeostasis. PROKR1 couples to Gq and Gi/o proteins, activating phospholipase C (PLC) and modulating calcium signaling, MAPK, and PI3K/Akt pathways. PROKR1 is widely expressed in endothelial cells, immune cells, and various organs, including the gastrointestinal tract, cardiovascular system, and reproductive tissues. It plays a critical role in regulating vascular growth, smooth muscle contraction, and inflammatory responses. In reproduction, PROKR1 is essential for implantation, placental development, and uterine function. Dysregulation of PROKR1 signaling has been linked to infertility, inflammatory diseases, and ischemic conditions, where impaired angiogenesis and inflammation occur. PROKR1 is also implicated in cancer progression, promoting tumor angiogenesis and metastasis. Therapeutic targeting of PROKR1 offers potential in treating reproductive disorders, inflammatory diseases, and cancers involving aberrant vascularization and tissue remodeling.
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