Pro-GRP Protein
936€ (100 µg)
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935106861
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name
Pro-GRP Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx060216
tested applications
ELISA, WB
Description
Pro-GRP Protein is a full-length recombinant protein with an N-terminal His tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Pro-GRP |
| Host | Fungus |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Sequence Fragment: Full length Pro-GRP Protein. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (pH 7.5). Does not contain preservatives. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07492 |
| Gene ID | 2922 |
| OMIM | 137260 |
| Alias | BN,GRP-10,proGRP,preproGRP |
| Background | Protein ProGRP |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Pro-Gastrin Releasing Peptide (ProGRP) is a precursor protein for gastrin-releasing peptide (GRP), a neuropeptide involved in a variety of physiological processes, including the regulation of gastric acid secretion, smooth muscle contraction, and pancreatic enzyme release. GRP is also known for its role in neural signaling, particularly in the central nervous system, where it modulates stress, memory, and circadian rhythm. ProGRP is a clinically significant biomarker, particularly in the diagnosis and monitoring of small cell lung cancer (SCLC), where elevated levels in serum are associated with disease presence and progression. The stability of ProGRP in circulation makes it a superior biomarker compared to GRP itself, as it provides a more reliable measure for diagnostic purposes. Beyond its use in oncology, ProGRP may play a role in gastrointestinal and neuroendocrine disorders, with its expression linked to cellular proliferation and secretion. Current research focuses on its potential as a therapeutic target in SCLC and other malignancies, as well as its broader role in neuroendocrine signaling pathways.
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