Human Pro-Gastrin Releasing Peptide (Pro-GRP) Protein
936€ (100 µg)
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Name
Human Pro-Gastrin Releasing Peptide (Pro-GRP) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx060265
Tested Applications
ELISA, WB
Description
Human Pro-GRP Protein (31-98 AA) is a recombinant protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Pro-Gastrin Releasing Peptide (Pro-GRP) |
| Host | E. coli |
| Assay Type | Sequence Fragment: 31-98 AA Tag: N-terminal GST tag. |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 10 mM Tris-HCl, pH 7.8 - 8.2. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20 °C or -80°C for long term. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07492 |
| Gene ID | 2922 |
| OMIM | 137260 |
| Alias | BN,GRP-10,proGRP,preproGRP |
| Background | Protein ProGRP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Pro-Gastrin Releasing Peptide (ProGRP) is a precursor protein for gastrin-releasing peptide (GRP), a neuropeptide involved in a variety of physiological processes, including the regulation of gastric acid secretion, smooth muscle contraction, and pancreatic enzyme release. GRP is also known for its role in neural signaling, particularly in the central nervous system, where it modulates stress, memory, and circadian rhythm. ProGRP is a clinically significant biomarker, particularly in the diagnosis and monitoring of small cell lung cancer (SCLC), where elevated levels in serum are associated with disease presence and progression. The stability of ProGRP in circulation makes it a superior biomarker compared to GRP itself, as it provides a more reliable measure for diagnostic purposes. Beyond its use in oncology, ProGRP may play a role in gastrointestinal and neuroendocrine disorders, with its expression linked to cellular proliferation and secretion. Current research focuses on its potential as a therapeutic target in SCLC and other malignancies, as well as its broader role in neuroendocrine signaling pathways.
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