GPR123-Specific Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
GPR123-Specific Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx233592
tested applications
ELISA, IHC
Description
GPR123-Specific Antibody is a Rabbit Polyclonal against GPR123-Specific.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | GPR123-Specific |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86SQ6 |
| Gene ID | 84435 |
| OMIM | 612302 |
| Alias | ADGRA1,GPR123 |
| Background | Antibody anti-ADGRA1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ADGRA1, also known as GPR123, is a member of the adhesion G protein-coupled receptor (GPCR) family, characterized by long extracellular domains facilitating cell-cell or cell-matrix interactions. This protein is highly expressed in the central nervous system and is implicated in neurodevelopmental processes, including axon guidance and synaptic formation. ADGRA1 contains a GPCR autoproteolysis-inducing (GAIN) domain, allowing for self-cleavage to regulate receptor activation. Its precise signaling mechanisms are still being studied, but it is believed to influence intracellular pathways like cAMP production and calcium mobilization. Dysregulation of ADGRA1 has been associated with neurological disorders and certain cancers, highlighting its relevance in both physiology and pathology.
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