Adhesion G Protein-Coupled Receptor A1 (ADGRA1) Antibody

Background

ADGRA1, also known as GPR123, is a member of the adhesion G protein-coupled receptor (GPCR) family, characterized by long extracellular domains facilitating cell-cell or cell-matrix interactions. This protein is highly expressed in the central nervous system and is implicated in neurodevelopmental processes, including axon guidance and synaptic formation. ADGRA1 contains a GPCR autoproteolysis-inducing (GAIN) domain, allowing for self-cleavage to regulate receptor activation. Its precise signaling mechanisms are still being studied, but it is believed to influence intracellular pathways like cAMP production and calcium mobilization. Dysregulation of ADGRA1 has been associated with neurological disorders and certain cancers, highlighting its relevance in both physiology and pathology.