anti- GPR123-Specific antibody

Este producto es parte de ADGRA - Adhesion G protein-coupled receptor A
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935106861
info@markelab.com
name
anti- GPR123-Specific antibody
category
Primary Antibodies
provider
FineTest
reference
FNab03592
tested applications
ELISA, IHC

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Data sheet

Product specifications

CategoryPrimary Antibodies
Immunogen TargetG protein-coupled receptor 123
HostRabbit
Reactivityhuman
Recommended DilutionIHC: 1:20-1:200
Clonalitypolyclonal
ConjugationUnconjugated
IsotypeIgG
Purity≥95% as determined by SDS-PAGE
PurificationImmunogen affinity purified
Size 1100µg
Formliquid
Tested ApplicationsELISA, IHC
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt IDQ86SQ6
AliasADGRA1,GPR124
BackgroundAntibody anti-ADGRA1
StatusRUO
NoteThis product is for research use only.

ADGRA1, also known as GPR123, is a member of the adhesion G protein-coupled receptor (GPCR) family, characterized by long extracellular domains facilitating cell-cell or cell-matrix interactions. This protein is highly expressed in the central nervous system and is implicated in neurodevelopmental processes, including axon guidance and synaptic formation. ADGRA1 contains a GPCR autoproteolysis-inducing (GAIN) domain, allowing for self-cleavage to regulate receptor activation. Its precise signaling mechanisms are still being studied, but it is believed to influence intracellular pathways like cAMP production and calcium mobilization. Dysregulation of ADGRA1 has been associated with neurological disorders and certain cancers, highlighting its relevance in both physiology and pathology.

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