G-Protein Coupled Receptor 124 (GPR124) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
G-Protein Coupled Receptor 124 (GPR124) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015297
tested applications
ELISA, IF/ICC
Description
Rabbit polyclonal antibody against GPR124 protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G-Protein Coupled Receptor 124 (GPR124) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IF/ICC: 1/100 - 1/500, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96PE1 |
| Alias | ADGRA2,GPR124 |
| Background | Antibody anti-ADGRA2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ADGRA2, also known as GPR124, is critical for angiogenesis, particularly in the central nervous system. It interacts with vascular endothelial growth factor (VEGF) signaling, mediating blood-brain barrier formation and vascular integrity. ADGRA2's extracellular domain includes thrombospondin type-1 repeats (TSRs), essential for binding to extracellular matrix components. This receptor also participates in Wnt/β-catenin signaling, pivotal for vascular development and stem cell maintenance. ADGRA2 is predominantly expressed in endothelial cells and neural tissues. Dysregulated expression or mutations in ADGRA2 have been linked to neurovascular disorders, glioblastomas, and other cancers, underscoring its significance in vascular biology.
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