Adhesion G Protein-Coupled Receptor A2 (ADGRA2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Adhesion G Protein-Coupled Receptor A2 (ADGRA2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212549
tested applications
ELISA, WB, IHC
Description
GPR124 Antibody is a Rabbit Polyclonal against GPR124.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adhesion G Protein-Coupled Receptor A2 (ADGRA2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96PE1 |
| Gene ID | 25960 |
| Alias | ADGRA2,GPR124 |
| Background | Antibody anti-ADGRA2 |
| Status | RUO |
Descripción
ADGRA2, also known as GPR124, is critical for angiogenesis, particularly in the central nervous system. It interacts with vascular endothelial growth factor (VEGF) signaling, mediating blood-brain barrier formation and vascular integrity. ADGRA2's extracellular domain includes thrombospondin type-1 repeats (TSRs), essential for binding to extracellular matrix components. This receptor also participates in Wnt/β-catenin signaling, pivotal for vascular development and stem cell maintenance. ADGRA2 is predominantly expressed in endothelial cells and neural tissues. Dysregulated expression or mutations in ADGRA2 have been linked to neurovascular disorders, glioblastomas, and other cancers, underscoring its significance in vascular biology.
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