ATP Binding Cassette Transporter D2 (ABCD2) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
ATP Binding Cassette Transporter D2 (ABCD2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130576
tested applications
WB, IHC, IF/ICC
Description
ABCD2 Antibody is a Rabbit Polyclonal against ABCD2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter D2 (ABCD2) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ABC39,ALDL1,ALDR,ALDRP |
| Background | Antibody anti-ABCD2 |
| Status | RUO |
Descripción
ABCD2 is a peroxisomal ATP-binding cassette transporter that plays a key role in the import of very-long-chain fatty acids (VLCFAs) and their derivatives into peroxisomes for β-oxidation. It is highly expressed in tissues such as the liver, brain, and adrenal glands, where VLCFA metabolism is essential for cellular function and homeostasis. Structurally, ABCD2 contains nucleotide-binding domains that drive ATP-dependent substrate transport across the peroxisomal membrane. ABCD2 shares functional redundancy with ABCD1, compensating for its loss in certain conditions such as X-linked adrenoleukodystrophy (X-ALD). Dysregulation of ABCD2 expression has been associated with metabolic disorders involving lipid accumulation and peroxisomal dysfunction, highlighting its importance in lipid metabolism and cellular health.
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