ATP Binding Cassette Transporter D2 (ABCD2) Antibody

Este producto es parte de ABCD - ATP Binding Cassette Transporter D
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286€ (100 µl)

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935106861
info@markelab.com
name
ATP Binding Cassette Transporter D2 (ABCD2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130576
tested applications
WB, IHC, IF/ICC

Description

ABCD2 Antibody is a Rabbit Polyclonal against ABCD2.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetATP Binding Cassette Transporter D2 (ABCD2)
HostRabbit
ReactivityMouse
Recommended DilutionWB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
PurificationPurified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1100 µl
Size 2200 µl
Size 31 ml
FormLiquid
Tested ApplicationsWB, IHC, IF/ICC
Buffer0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
AvailabilityShipped within 5-7 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
AliasABC39,ALDL1,ALDR,ALDRP
BackgroundAntibody anti-ABCD2
StatusRUO

Descripción

ABCD2 is a peroxisomal ATP-binding cassette transporter that plays a key role in the import of very-long-chain fatty acids (VLCFAs) and their derivatives into peroxisomes for β-oxidation. It is highly expressed in tissues such as the liver, brain, and adrenal glands, where VLCFA metabolism is essential for cellular function and homeostasis. Structurally, ABCD2 contains nucleotide-binding domains that drive ATP-dependent substrate transport across the peroxisomal membrane. ABCD2 shares functional redundancy with ABCD1, compensating for its loss in certain conditions such as X-linked adrenoleukodystrophy (X-ALD). Dysregulation of ABCD2 expression has been associated with metabolic disorders involving lipid accumulation and peroxisomal dysfunction, highlighting its importance in lipid metabolism and cellular health.
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