ATP Binding Cassette Subfamily D Member 2 (ABCD2) Antibody
357.5€ (100 µg)
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name
ATP Binding Cassette Subfamily D Member 2 (ABCD2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037500
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ABCD2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily D Member 2 (ABCD2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_005164 |
| Alias | ABC39,ALDL1,ALDR,ALDRP |
| Background | Antibody anti-ABCD2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ABCD2 is a peroxisomal ATP-binding cassette transporter that plays a key role in the import of very-long-chain fatty acids (VLCFAs) and their derivatives into peroxisomes for β-oxidation. It is highly expressed in tissues such as the liver, brain, and adrenal glands, where VLCFA metabolism is essential for cellular function and homeostasis. Structurally, ABCD2 contains nucleotide-binding domains that drive ATP-dependent substrate transport across the peroxisomal membrane. ABCD2 shares functional redundancy with ABCD1, compensating for its loss in certain conditions such as X-linked adrenoleukodystrophy (X-ALD). Dysregulation of ABCD2 expression has been associated with metabolic disorders involving lipid accumulation and peroxisomal dysfunction, highlighting its importance in lipid metabolism and cellular health.
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