ABCD2 antibody
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935106861
info@markelab.com
name
ABCD2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00038
tested applications
ELISA, WB, IP
Description
Probable transporter.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-binding cassette, sub-family D(ALD), member 2 (ABCD2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:1000; IP: 1:200-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 80 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UBJ2 |
| Gene ID | 225 |
| Alias | ABC39,ALDL1,ALDR,ALDRP |
| Background | Antibody anti-ABCD2 |
| Status | RUO |
| Note | Mol. Weight 80 kDa |
Descripción
ABCD2 is a peroxisomal ATP-binding cassette transporter that plays a key role in the import of very-long-chain fatty acids (VLCFAs) and their derivatives into peroxisomes for β-oxidation. It is highly expressed in tissues such as the liver, brain, and adrenal glands, where VLCFA metabolism is essential for cellular function and homeostasis. Structurally, ABCD2 contains nucleotide-binding domains that drive ATP-dependent substrate transport across the peroxisomal membrane. ABCD2 shares functional redundancy with ABCD1, compensating for its loss in certain conditions such as X-linked adrenoleukodystrophy (X-ALD). Dysregulation of ABCD2 expression has been associated with metabolic disorders involving lipid accumulation and peroxisomal dysfunction, highlighting its importance in lipid metabolism and cellular health.
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