ATP Binding Cassette Subfamily D Member 2 (ABCD2) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
ATP Binding Cassette Subfamily D Member 2 (ABCD2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230038
tested applications
ELISA, WB, IP
Description
ABCD2 Antibody is a Rabbit Polyclonal against ABCD2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily D Member 2 (ABCD2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/200 - 1/1000, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UBJ2 |
| Gene ID | 225 |
| OMIM | 601081 |
| Alias | ABC39,ALDL1,ALDR,ALDRP |
| Background | Antibody anti-ABCD2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ABCD2 is a peroxisomal ATP-binding cassette transporter that plays a key role in the import of very-long-chain fatty acids (VLCFAs) and their derivatives into peroxisomes for β-oxidation. It is highly expressed in tissues such as the liver, brain, and adrenal glands, where VLCFA metabolism is essential for cellular function and homeostasis. Structurally, ABCD2 contains nucleotide-binding domains that drive ATP-dependent substrate transport across the peroxisomal membrane. ABCD2 shares functional redundancy with ABCD1, compensating for its loss in certain conditions such as X-linked adrenoleukodystrophy (X-ALD). Dysregulation of ABCD2 expression has been associated with metabolic disorders involving lipid accumulation and peroxisomal dysfunction, highlighting its importance in lipid metabolism and cellular health.
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