Acyl Coenzyme A Synthetase Medium Chain Family, Member 1 (ACSM1) Antibody

Background

ACSM1 is an enzyme that activates medium-chain fatty acids by converting them into acyl-CoA esters, a key step in their metabolism for β-oxidation and lipid biosynthesis. It is primarily expressed in the liver and kidneys, where it contributes to the catabolism of dietary medium-chain fatty acids and their incorporation into energy production pathways. ACSM1 supports metabolic flexibility by facilitating the rapid oxidation of medium-chain fatty acids during fasting or high-fat dietary conditions. It also plays a role in detoxification pathways by processing fatty acid derivatives and xenobiotics. Dysregulation of ACSM1 activity has been associated with metabolic imbalances, particularly in conditions where medium-chain fatty acid metabolism is impaired, such as certain forms of fatty acid oxidation disorders. Its specificity for medium-chain substrates highlights its role in maintaining energy homeostasis and lipid processing.