A-Kinase Anchor Protein 2 (AKAP2) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
A-Kinase Anchor Protein 2 (AKAP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx119572
tested applications
WB
Description
AKAP2 Antibody is a Rabbit Polyclonal antibody against AKAP2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchor Protein 2 (AKAP2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y2D5 |
| Alias | PALM2AKAP2,KIAA0920, PAKAP |
| Background | Antibody anti-AKAP2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AKAP2, also called AKAP-KL, is a dual-targeting scaffold protein that interacts with PKA, phospholipase C (PLC), and signaling proteins near cellular membranes. AKAP2 is highly expressed in endothelial cells, where it regulates cytoskeletal remodeling, cell adhesion, and vascular homeostasis. It organizes PKA signaling at the plasma membrane to control focal adhesion turnover and actin cytoskeleton dynamics, critical for endothelial barrier function and angiogenesis. AKAP2 interacts with membrane receptors and small GTPases, linking it to signaling pathways that regulate migration, adhesion, and proliferation in vascular tissues. Dysregulation of AKAP2 has been implicated in cardiovascular diseases, as loss of its function disrupts endothelial integrity and angiogenic signaling. Additionally, AKAP2 plays a role in neuronal development and synaptic plasticity, where its cytoskeletal organization supports neurite outgrowth and network formation.
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