Family main features
TIR domain-containing adaptor molecule (TICAM), also known as TRIF (TIR-domain-containing adapter-inducing interferon-β), is a critical adaptor protein involved in the Toll-like receptor (TLR) signaling pathway, specifically mediating signals from TLR3 and TLR4. This signaling pathway is essential for the innate immune response, particularly in recognizing pathogen-associated molecular patterns (PAMPs) and initiating appropriate immune responses. TICAM plays a pivotal role in the production of type I interferons and pro-inflammatory cytokines, which are crucial for antiviral responses and inflammation regulation. The identification of TICAM has provided significant insights into the molecular mechanisms of innate immunity and the body's first line of defense against infections.
TICAM is characterized by several functional domains:
TICAM belongs to the family of TIR-domain-containing adaptors, which include other important molecules like MyD88, TIRAP (Mal), and TRAM. These adaptors are essential for mediating TLR signaling, each having specific roles in different branches of the signaling pathways.
TICAM plays several key roles in cellular signaling and immune responses:
Dysregulation or mutations in TICAM are associated with various diseases:
TIR domain-containing adaptor molecule (TICAM), also known as TRIF, is a critical component of the TLR signaling pathway, specifically mediating signals from TLR3 and TLR4. It plays a central role in the innate immune response by facilitating the production of type I interferons and pro-inflammatory cytokines, crucial for antiviral defense and inflammation regulation. TICAM's structure includes a TIR domain, a proline-rich region, and an intermediate domain that facilitate interactions with other signaling proteins. Dysregulation of TICAM is linked to autoimmune diseases, infectious diseases, inflammatory disorders, and cancer, underscoring its importance in immune regulation and its potential as a therapeutic target. Understanding the mechanisms of TICAM function and regulation provides valuable insights into the treatment of these conditions.
TIR domain containing adaptor molecule 1 (TICAM1)
TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1
TIR domain-containing adapter molecule 2 (TICAM2)
MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, toll like receptor adaptor molecule 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con TICAM - TIR domain containing adaptor molecule
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Esta página contiene 30 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | TICAM1 | abx495355 | Human Toll Like Receptor Adaptor Molecule 1 (TICAM1) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 78 pg/ml - 5000 pg/ml | < 31 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | TICAM1 | abx153295 | Human Toll Like Receptor Adaptor Molecule 1 (TICAM1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 31 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | TICAM2 | abx383756 | Human TIR domain-containing adapter molecule 2 (TICAM2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q86XR7 | RUO |
Abbexa | TICAM1 | abx495356 | Mouse Toll Like Receptor Adaptor Molecule 1 (TICAM1) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 62.5 pg/ml - 4000 pg/ml | < 22.9 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | TICAM1 | abx154760 | Mouse Toll Like Receptor Adaptor Molecule 1 (TICAM1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 62.5 pg/ml - 4000 pg/ml | < 21.7 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | TICAM2 | abx549039 | Mouse TIR domain-containing adapter molecule 2 (TICAM2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8BJQ4 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | TICAM2 | FNab08687 | anti- TICAM2 antibody | human | polyclonal | Rabbit | toll-like receptor adaptor molecule 2 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q86XR7 | RUO | |
Abbexa | TICAM1 | abx129122 | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 1 (TICAM1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q8IUC6 | RUO | |
Abbexa | TICAM1 | abx174847 | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor Adaptor Molecule 1 (TICAM1) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | TICAM1 | abx219127 | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 1 (TICAM1) | Unconjugated | ELISA, WB | 350 | 100 µg | Q8IUC6 | RUO | |
Abbexa | TICAM1 | abx325000 | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 1 (TICAM1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q8IUC6 | RUO | |
Abbexa | TICAM1 | abx433607 | TIR Domain-Containing Adapter Molecule 1 (TICAM1) Antibody | Human | Polyclonal | Goat | TIR Domain-Containing Adapter Molecule 1 (TICAM1) | Unconjugated | P-ELISA, IHC, FCM | 387.5 | 200 µl | RUO | ||
Abbexa | TICAM1 | abx430774 | TIR Domain-Containing Adapter Molecule 1 (TICAM-1) Antibody | Human | Polyclonal | Goat | TIR Domain-Containing Adapter Molecule 1 (TICAM-1) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | TICAM1 | abx034891 | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 1 (TICAM1) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q8IUC6 | RUO | |
Abbexa | TICAM1 | abx001069 | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 1 (TICAM1) | Unconjugated | WB | 175 | 20 µl | Q8IUC6-1 | RUO | |
Abbexa | TICAM1 | abx117043 | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 1 (TICAM1) | Unconjugated | ELISA, WB, IHC | 450 | 100 µl | Q8IUC6 | RUO | |
Abbexa | TICAM2 | abx006188 | TIR Domain-Containing Adapter Molecule 2 (TICAM2) Antibody | Human | Polyclonal | Rabbit | TIR Domain-Containing Adapter Molecule 2 (TICAM2) | Unconjugated | WB | 175 | 20 µl | Q86XR7 | RUO | |
Abbexa | TICAM2 | abx027777 | TIR Domain-Containing Adapter Molecule 2 (TICAM2) Antibody | Human | Polyclonal | Rabbit | TIR Domain-Containing Adapter Molecule 2 (TICAM2) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q86XR7 | RUO | |
Abbexa | TICAM2 | abx320546 | TIR Domain-Containing Adapter Molecule 2 (TICAM2) Antibody | Human | Polyclonal | Rabbit | TIR Domain-Containing Adapter Molecule 2 (TICAM2) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | Q86XR7 | RUO | |
Abbexa | TICAM2 | abx104101 | Toll Like Receptor Adaptor Molecule 2 (TICAM2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 2 (TICAM2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | TICAM2 | abx238687 | TIR Domain-Containing Adapter Molecule 2 (TICAM2) Antibody | Human | Polyclonal | Rabbit | TIR Domain-Containing Adapter Molecule 2 (TICAM2) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q86XR7 | RUO | |
Abbexa | TICAM2 | abx210249 | Toll Like Receptor Adaptor Molecule 2 (TICAM2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 2 (TICAM2) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q86XR7 | RUO | |
Abbexa | TICAM2 | abx339435 | Toll Like Receptor Adaptor Molecule 2 (TICAM2) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 2 (TICAM2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q86XR7 | RUO | |
Abbexa | TICAM1 | abx129792 | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 1 (TICAM1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q80UF7 | RUO | |
Abbexa | TICAM2 | abx129378 | Toll Like Receptor Adaptor Molecule 2 (TICAM2) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor Adaptor Molecule 2 (TICAM2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TICAM1 | abx167484 | Mouse Toll Like Receptor Adaptor Molecule 1 (TICAM1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | RUO | |
Abbexa | TICAM1 | abx167094 | Human Toll Like Receptor Adaptor Molecule 1 (TICAM1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q8IUC6 | RUO |
Abbexa | TICAM2 | abx167454 | Mouse Toll Like Receptor Adaptor Molecule 2 (TICAM2) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | TICAM2 | abx262494 | Toll-Like Receptor Adaptor Molecule 2 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q86XR7 | RUO | ||
FineTest | TICAM2 | P6128 | Recombinant Human TICAM2 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q86XR7 | RUO |
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