Mouse Toll Like Receptor Adaptor Molecule 1 (TICAM1) Protein
247€ (10 µg)
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Name
Mouse Toll Like Receptor Adaptor Molecule 1 (TICAM1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx167484
Tested Applications
WB, SDS-PAGE
Description
Mouse Toll Like Receptor Adaptor Molecule 1 Protein is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Toll Like Receptor Adaptor Molecule 1 (TICAM1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser263-Val526 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 32.1 kDa Observed MW (SDS-PAGE): 39 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1 |
| Background | Protein TICAM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
TICAM1, also known as TRIF (TIR-domain-containing adapter-inducing interferon-β), is a key adaptor protein in Toll-like receptor (TLR) signaling, specifically downstream of TLR3 and TLR4. It mediates activation of type I interferon (IFN) responses and pro-inflammatory cytokine production through pathways like IRF3/7 and NF-κB. TICAM1 functions by recruiting downstream signaling molecules, including TBK1, TRAF6, and RIP1, to activate antiviral responses and innate immunity. It is essential for host defense against viral infections, where its activation triggers IFN-β production and inflammatory responses to double-stranded RNA and bacterial components. TICAM1 is widely expressed in immune cells and epithelial tissues, ensuring effective pathogen recognition and elimination. Dysregulation of TICAM1 is associated with immune deficiencies, chronic inflammation, and autoimmune diseases due to impaired or excessive IFN signaling. Knockout studies demonstrate increased susceptibility to viral infections, reduced IFN production, and impaired TLR3/TLR4-mediated immune responses, highlighting its role in antiviral defense and innate immunity.
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