TIR Domain-Containing Adapter Molecule 1 (TICAM1) Antibody

Este producto es parte de TICAM - TIR domain containing adaptor molecule
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416€ (200 µl)

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935106861
info@markelab.com
name
TIR Domain-Containing Adapter Molecule 1 (TICAM1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433607
tested applications
P-ELISA, IHC, FCM

Description

TIR Domain-Containing Adapter Molecule 1 (TICAM1) Antibody is a Goat Polyclonal antibody against TIR Domain-Containing Adapter Molecule 1 (TICAM1).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
TIR Domain-Containing Adapter Molecule 1 (TICAM1)
Host
Goat
Reactivity
Human
Recommended Dilution
P-ELISA: 1/64000, IHC: 2.5 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, IHC, FCM
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
148022
NCBI Accession
NP_891549.1
Alias
TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1
Background
Antibody anti-TICAM1
Status
RUO
Note
Concentration: 0.5 mg/ml - 

Descripción

TICAM1, also known as TRIF (TIR-domain-containing adapter-inducing interferon-β), is a key adaptor protein in Toll-like receptor (TLR) signaling, specifically downstream of TLR3 and TLR4. It mediates activation of type I interferon (IFN) responses and pro-inflammatory cytokine production through pathways like IRF3/7 and NF-κB. TICAM1 functions by recruiting downstream signaling molecules, including TBK1, TRAF6, and RIP1, to activate antiviral responses and innate immunity. It is essential for host defense against viral infections, where its activation triggers IFN-β production and inflammatory responses to double-stranded RNA and bacterial components. TICAM1 is widely expressed in immune cells and epithelial tissues, ensuring effective pathogen recognition and elimination. Dysregulation of TICAM1 is associated with immune deficiencies, chronic inflammation, and autoimmune diseases due to impaired or excessive IFN signaling. Knockout studies demonstrate increased susceptibility to viral infections, reduced IFN production, and impaired TLR3/TLR4-mediated immune responses, highlighting its role in antiviral defense and innate immunity.

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