Toll-Like Receptor Adaptor Molecule 2 Protein

Este producto es parte de TICAM - TIR domain containing adaptor molecule
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234€ (2 µg)

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935106861
info@markelab.com
name
Toll-Like Receptor Adaptor Molecule 2 Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx262494
tested applications
SDS-PAGE

Description

TICAM2 is a recombinant protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
TICAM2
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 85% (SDS-PAGE)
Size 1
2 µg
Size 2
10 µg
Size 3
1 mg
Form
Liquid 
Tested Applications
SDS-PAGE
Availability
Shipped within 5-10 working days.
Dry Ice
No
UniProt ID
Q86XR7
Alias
MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, toll like receptor adaptor molecule 2
Background
Protein TICAM2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

TICAM2, also known as TRAM (TRIF-related adaptor molecule), is an adaptor protein that functions specifically in Toll-like receptor 4 (TLR4) signaling. It facilitates MyD88-independent pathways, mediating the activation of IRF3 and NF-κB to induce type I interferon and pro-inflammatory cytokine production. TICAM2 acts as a bridge between TLR4 and TICAM1, enabling signaling responses to lipopolysaccharides (LPS) and other pathogen-associated molecular patterns (PAMPs) in Gram-negative bacterial infections. TICAM2 is expressed primarily in immune and epithelial cells, where it contributes to early innate immune responses. Dysregulation of TICAM2 impairs TLR4-mediated IFN-β production and inflammatory signaling, leading to defective immune responses to bacterial infections or chronic inflammation in certain conditions. Knockout studies reveal a loss of MyD88-independent signaling, reduced IRF3 activation, and increased susceptibility to bacterial infections, underscoring its specific and essential role in TLR4 signaling pathways.

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