Toll-Like Receptor Adaptor Molecule 2 Protein

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Description
TICAM2 is a recombinant protein.
Documents del producto
Product specifications
Category | Proteins and Peptides |
Immunogen Target | TICAM2 |
Conjugation | Unconjugated |
Expression | Recombinant |
Purity | > 85% (SDS-PAGE) |
Size 1 | 2 µg |
Size 2 | 10 µg |
Size 3 | 1 mg |
Form | Liquid |
Tested Applications | SDS-PAGE |
Availability | Shipped within 5-10 working days. |
Dry Ice | No |
UniProt ID | Q86XR7 |
Alias | MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, toll like receptor adaptor molecule 2 |
Background | Protein TICAM2 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TICAM2, also known as TRAM (TRIF-related adaptor molecule), is an adaptor protein that functions specifically in Toll-like receptor 4 (TLR4) signaling. It facilitates MyD88-independent pathways, mediating the activation of IRF3 and NF-κB to induce type I interferon and pro-inflammatory cytokine production. TICAM2 acts as a bridge between TLR4 and TICAM1, enabling signaling responses to lipopolysaccharides (LPS) and other pathogen-associated molecular patterns (PAMPs) in Gram-negative bacterial infections. TICAM2 is expressed primarily in immune and epithelial cells, where it contributes to early innate immune responses. Dysregulation of TICAM2 impairs TLR4-mediated IFN-β production and inflammatory signaling, leading to defective immune responses to bacterial infections or chronic inflammation in certain conditions. Knockout studies reveal a loss of MyD88-independent signaling, reduced IRF3 activation, and increased susceptibility to bacterial infections, underscoring its specific and essential role in TLR4 signaling pathways.
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