QRFPR - Pyroglutamylated RFamide peptide receptor | Elisa - Clia - Antibody - Protein

Background:

QRFPR, also known as the pyroglutamylated RFamide peptide receptor or GPR103, is a G protein-coupled receptor (GPCR) that binds to RFamide peptides. It was identified through orphan GPCR screening and deorphanization efforts aimed at discovering novel receptors and their ligands. This receptor is implicated in various physiological processes, including regulation of appetite, energy homeostasis, and cardiovascular function.QRFPR, or the pyroglutamylated RFamide peptide receptor, is a GPCR that binds RFamide peptides like 26RFa and 43RFa. It plays significant roles in regulating appetite, energy homeostasis, cardiovascular function, and neuroendocrine processes. Alterations in its function are linked to obesity, cardiovascular diseases, and potential mental health disorders. Targeting QRFPR offers promising therapeutic potential for these conditions

Structural Features:

QRFPR, like other GPCRs, is characterized by its seven-transmembrane helical structure. It includes:

• Extracellular N-terminal domain: This region is involved in ligand binding.
• Seven transmembrane helices: These helices span the cell membrane and are connected by intra- and extracellular loops.
• Intracellular C-terminal domain: This part interacts with G proteins and is crucial for initiating intracellular signaling pathways.

Subtypes and Classification:

Currently, QRFPR is classified as a single receptor without identified subtypes. It belongs to the class A (rhodopsin-like) family of GPCRs.

Ligands:

QRFPR primarily binds to RFamide peptides, including:

• 26RFa (QRFP26): A neuropeptide that acts as the endogenous ligand for QRFPR.
• 43RFa (QRFP43): Another form of the RFamide peptide, which can also activate QRFPR.

Physiological Functions:

QRFPR is involved in a variety of physiological processes:

• Regulation of Appetite and Energy Homeostasis: QRFPR activation by its ligands can stimulate feeding behavior and promote energy storage. This makes it an important regulator of body weight and metabolism.
• Cardiovascular Function: QRFPR has been implicated in the regulation of blood pressure and cardiovascular function.
• Neuroendocrine Functions: The receptor is expressed in the hypothalamus and other brain regions, suggesting roles in neuroendocrine regulation and behavioral responses.

Clinical Implications:

Alterations in QRFPR signaling have been linked to several conditions:

• Obesity: Dysregulation of QRFPR activity can contribute to obesity and related metabolic disorders by affecting appetite and energy balance.
• Cardiovascular Diseases: Given its role in cardiovascular regulation, QRFPR may be a target for treating hypertension and other cardiovascular conditions.
• Mental Health: Potential involvement in neuroendocrine functions suggests that QRFPR could be relevant in disorders such as anxiety and depression.

Therapeutic Potential:

Understanding QRFPR and its ligands offers potential therapeutic applications:

• Anti-obesity Treatments: Modulating QRFPR activity could lead to new treatments for obesity by controlling appetite and energy expenditure.
• Cardiovascular Drugs: Targeting QRFPR may provide new approaches for managing blood pressure and cardiovascular health.
• Psychiatric Therapies: Investigating the role of QRFPR in the brain could reveal new targets for treating mental health disorders.