Pyroglutamylated RFamide Peptide Receptor (QRFPR) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Pyroglutamylated RFamide Peptide Receptor (QRFPR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030023
tested applications
ELISA, WB
Description
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pyroglutamylated RFamide Peptide Receptor (QRFPR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96P65 |
| Alias | QRFPR,AQ27,SP9155,GPR103,G protein-coupled receptor 103,peptide p518 receptor |
| Background | Antibody anti-QRFPR |
| Status | RUO |
Descripción
QRFPR is a G protein-coupled receptor (GPCR) activated by pyroglutamylated RFamide peptides, a family of neuropeptides that play a role in regulating physiological processes such as pain modulation, feeding behavior, and hormone secretion. QRFPR primarily couples to Gq proteins, stimulating phospholipase C (PLC) and increasing intracellular calcium, leading to downstream cellular responses. It is expressed in the central nervous system, particularly in regions involved in appetite control and reward systems, as well as in peripheral tissues involved in hormone regulation. QRFPR is involved in modulating sensory processing, specifically in nociception, by influencing pain pathways. Dysregulation of QRFPR signaling is implicated in disorders related to metabolism and pain. This receptor's unique role in mediating these processes makes it a potential target for therapeutic interventions aimed at treating pain and metabolic disorders.
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