Family main features
Palladin is a cytoskeletal-associated protein that plays a crucial role in the organization and function of the actin cytoskeleton. The actin cytoskeleton is essential for various cellular processes, including cell shape maintenance, migration, and adhesion. Palladin was first identified through its interaction with alpha-actinin and has since been found to interact with other cytoskeletal proteins, implicating it in a wide range of cellular functions.
Palladin is encoded by the PALLD gene located on chromosome 4q32.3. The gene is highly conserved across species, highlighting its importance in cellular function. Palladin is ubiquitously expressed in various tissues, with particularly high levels in the heart, smooth muscle, and skeletal muscle, suggesting a fundamental role in maintaining the structural integrity and function of these tissues.
Palladin is a multi-domain protein that can vary in size due to alternative splicing. The main structural features of palladin include:
Palladin exists in multiple isoforms, which vary in their domain composition and length, leading to differences in their functional properties and cellular localization.
Palladin is part of the larger family of cytoskeletal proteins that interact with actin filaments. The various isoforms of palladin, produced through alternative splicing, can be classified based on their size and domain composition. The major isoforms include:
Palladin plays a vital role in various cellular processes:
Palladin has been implicated in several diseases and pathological conditions:
Palladin is a key cytoskeletal-associated protein that plays a fundamental role in the organization and function of the actin cytoskeleton. Its structure includes multiple Ig domains, proline-rich regions, and alpha-helical coiled-coil domains, enabling interactions with various cytoskeletal proteins and signaling molecules. Palladin exists in multiple isoforms, each contributing to different cellular processes, including cell shape maintenance, migration, adhesion, and signal transduction.
Clinically, palladin is significant due to its involvement in cancer, cardiovascular diseases, and fibrotic conditions. Its role in enhancing cell migration and invasion in cancer highlights its potential as a therapeutic target. Further research into palladin's functions and regulatory mechanisms will provide deeper insights into its roles in health and disease, offering potential avenues for novel therapeutic strategies.
palladin, cytoskeletal associated protein (PALLD)
MYN,PNCA1,CGI151,SIH002,CGI-151,SIH002,Sarcoma antigen NY-SAR-77
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con PALLD - palladin cytoskeletal associated protein
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 17 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PALLD | abx492894 | Human Palladin (PALLD) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.051 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | PALLD | abx152630 | Human Palladin (PALLD) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | PALLD | abx390143 | Mouse Palladin (Palld) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q9ET54 | RUO |
Abbexa | PALLD | abx391766 | Rat Palladin (Palld) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | P0C5E3 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PALLD | abx433088 | Palladin (PALLD) Antibody | Polyclonal | Goat | Palladin (PALLD) | Unconjugated | P-ELISA | 250 | 200 µl | RUO | |||
Abbexa | PALLD | abx130939 | Palladin (PALLD) Antibody | Human | Polyclonal | Rabbit | Palladin (PALLD) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q8WX93 | RUO | |
Abbexa | PALLD | abx432156 | Palladin (PALLD) Antibody | Human | Polyclonal | Goat | Palladin (PALLD) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | PALLD | abx173941 | Palladin (PALLD) Antibody | Human | Monoclonal | Mouse | Palladin (PALLD) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | PALLD | abx376423 | Palladin (PALLD) Antibody | Human | Polyclonal | Rabbit | Palladin (PALLD) | Unconjugated | ELISA, WB, IHC, IF/ICC | 225 | 50 µg | Q8WX93 | RUO | |
Abbexa | PALLD | abx433089 | Pallidin Antibody | Human | Polyclonal | Goat | Pallidin | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | PALLD | abx236127 | Palladin-Specific Antibody | Human | Polyclonal | Rabbit | Palladin-Specific | Unconjugated | ELISA, WB, IP | 350 | 100 µg | Q8WX93 | RUO | |
Abbexa | PALLD | abx375161 | Palladin (PALLD) Antibody | Human | Polyclonal | Rabbit | Palladin (PALLD) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | Q8WX93 | RUO | |
Abbexa | PALLD | abx236126 | Palladin (PALLD) Antibody | Human | Polyclonal | Rabbit | Palladin (PALLD) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM, IP | 350 | 100 µg | Q8WX93 | RUO | |
Abbexa | PALLD | abx325204 | Palladin (PALLD) Antibody | Human | Polyclonal | Rabbit | Palladin (PALLD) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | Q8WX93 | RUO | |
Abbexa | PALLD | abx126318 | Palladin (PALLD) Antibody | Human | Polyclonal | Rabbit | Palladin (PALLD) | Unconjugated | WB, IHC | 175 | 20 µl | Q8WX93 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | PALLD | P2061 | Recombinant Human PALLD | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q8WX93 | RUO | ||
Abbexa | PALLD | abx168708 | Human Palladin (PALLD) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | Q8WX93 | RUO |
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