NR5A - nuclear receptor subfamily 5 group A member | Elisa - Clia - Antibody - Protein

Family main features

Background

The NR5A family, also known as the nuclear receptor subfamily 5 group A, encompasses a group of orphan nuclear receptors that play pivotal roles in various physiological processes, including development, metabolism, and reproduction. This family includes two main members: NR5A1 (also known as Steroidogenic Factor-1, SF-1) and NR5A2 (also known as Liver Receptor Homolog-1, LRH-1). These receptors are highly conserved and are essential for the regulation of genes involved in steroidogenesis, bile acid synthesis, and glucose metabolism. NR5A receptors are expressed in a wide range of tissues, such as the adrenal glands, gonads, liver, and pancreas, highlighting their importance in endocrine and metabolic functions.


Protein Structure

The structure of NR5A receptors includes:

  • N-terminal Domain (NTD): Contains activation function-1 (AF-1) domain, which is involved in ligand-independent transcriptional activation.
  • DNA-binding Domain (DBD): Characterized by two zinc finger motifs that facilitate binding to specific DNA sequences, such as response elements in target gene promoters.
  • Hinge Region: Connects the DBD to the ligand-binding domain (LBD) and includes nuclear localization signals.
  • Ligand-binding Domain (LBD): This domain is essential for the receptor's interaction with co-regulators and potential ligands, although NR5A receptors are often classified as orphan receptors due to the absence of well-defined endogenous ligands.


Classification and Subtypes

The NR5A family consists of:

  • NR5A1 (SF-1): Primarily involved in steroid hormone biosynthesis and sexual development.
  • NR5A2 (LRH-1): Plays a crucial role in bile acid homeostasis, cholesterol metabolism, and glucose homeostasis.


Function and Biological Significance

  • Steroidogenesis: NR5A1 regulates genes involved in the synthesis of steroid hormones, such as CYP11A1, which is crucial for the conversion of cholesterol to pregnenolone.
  • Sexual Development: NR5A1 is essential for the development of the adrenal glands and gonads, influencing sex determination and differentiation.
  • Metabolism: NR5A2 regulates genes involved in bile acid synthesis (e.g., CYP7A1) and glucose metabolism (e.g., PEPCK).
  • Cell Proliferation and Differentiation: Both NR5A1 and NR5A2 are involved in cell proliferation and differentiation processes in various tissues, including the liver and pancreas.


Clinical Issues

  • Congenital Adrenal Hyperplasia (CAH): Mutations in NR5A1 are linked to CAH, a condition characterized by impaired steroidogenesis.
  • Disorders of Sexual Development (DSD): NR5A1 mutations can lead to gonadal dysgenesis and various forms of DSD.
  • Cancer: NR5A2 has been implicated in various cancers, including pancreatic, colorectal, and breast cancers, where it may influence tumor growth and progression through its metabolic and proliferative functions.
  • Metabolic Disorders: Dysregulation of NR5A2 can contribute to metabolic syndromes, including obesity, diabetes, and fatty liver disease.


Summary

The NR5A family of nuclear receptors, comprising NR5A1 and NR5A2, is integral to the regulation of steroidogenesis, sexual development, and metabolism. These receptors have a characteristic nuclear receptor structure with NTD, DBD, hinge region, and LBD. They bind to specific DNA sequences to regulate the expression of target genes involved in critical physiological processes. Clinical implications of NR5A dysregulation include congenital adrenal hyperplasia, disorders of sexual development, various cancers, and metabolic disorders. Understanding the roles and regulatory mechanisms of NR5A receptors is crucial for developing therapeutic strategies for related diseases.


NR5A1 Recommended name:

nuclear receptor subfamily 5 group A member 1 (NR5A1)

Aliases for NR5A1

ELP,SF1,FTZ1,POF7,SF-1,AD4BP,FTZF1,SPGF8,SRXX4,SRXY3,hSF-1,Steroidogenic factor 1,Fushi tarazu factor homolog 1,Nuclear receptor subfamily 5 group A member 1,Adrenal 4-binding protein

NR5A2 Recommended name:

nuclear receptor subfamily 5 group A member 2 (NR5A2)

Aliases for NR5A2

B1F.CPF,FTF,B1F2,LRH1,LRH-1,FTZ-F1,hB1F-2,FTZ-F1beta,Alpha-1-fetoprotein transcription factor,CYP7A promoter-binding factor,Hepatocytic transcription factor

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits, Proteins and Peptides, CLIA Kits) relacionados con NR5A - nuclear receptor subfamily 5 group A member

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Esta página contiene 34 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaNR5A2abx512512Chicken Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA KitChickenTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsO42101RUO
AbbexaNR5A1abx351711Human Steroidogenic Factor 1 (NR5A1) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluidsSandwich31.2 pg/ml - 2000 pg/ml18.8 pg/ml52596 testsQ13285RUO
AbbexaNR5A2abx152231Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA KitHumanTissue homogenates,Other biological fluidsSandwich0.312 ng/ml - 20 ng/ml< 0.12 ng/ml687.596 testsRUO
AbbexaNR5A2abx512513Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluidsSandwich78 pg/ml - 5000 pg/ml< 39 pg/ml687.596 testsO00482RUO
AbbexaNR5A2abx494460Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) CLIA KitHumanTissue homogenates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.112 ng/ml84596 testsRUO
AbbexaNR5A1abx353071Mouse Steroidogenic Factor 1 (NR5A1) ELISA KitMouseTissue homogenates,Cell lysates,Other biological fluidsSandwich31.2 pg/ml - 2000 pg/ml18.8 pg/ml587.596 testsP33242RUO
AbbexaNR5A2abx512514Mouse Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA KitMouseTissue homogenates,Cell lysates,Other biological fluidsSandwich78 pg/ml - 5000 pg/ml< 39.1 pg/ml687.596 testsP45448RUO
AbbexaNR5A1abx361805Pig Steroidogenic Factor 1 (NR5A1) ELISA KitPigSerum,Plasma,Other biological fluidsSandwich31.2 pg/ml - 2000 pg/ml18.8 pg/ml687.596 testsRUO
AbbexaNR5A1abx353939Rat Steroidogenic Factor 1 (NR5A1) ELISA KitRatTissue homogenates,Cell lysates,Other biological fluidsSandwich31.2 pg/ml - 2000 pg/ml18.8 pg/ml587.596 testsP50569RUO
AbbexaNR5A2abx494461Rat Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) CLIA KitRatTissue homogenates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.063 ng/ml84596 testsRUO
AbbexaNR5A2abx512515Rat Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA KitRatTissue homogenates,Cell lysates,Other biological fluidsSandwich0.156 ng/ml - 10 ng/ml< 0.083 ng/ml687.596 testsQ9QWM1RUO
AbbexaNR5A2abx155790Rat Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA KitRatTissue homogenates,Other biological fluidsSandwich0.156 ng/ml - 10 ng/ml< 0.07 ng/ml687.596 testsRUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestNR5A1FNab05847anti- NR5A1 antibodyhumanpolyclonalRabbitnuclear receptor subfamily 5, group A, member 1IgGUnconjugatedELISA, WB, IHC, IP100µgQ13285RUO
FineTestNR5A2FNab05848anti- NR5A2 antibodyhumanpolyclonalRabbitnuclear receptor subfamily 5, group A, member 2IgGUnconjugatedELISA, WB100µgO00482RUO
AbbexaNR5A1abx032414Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 1 (NR5A1)UnconjugatedELISA, WB, IHC, FCM25080 µlQ13285RUO
AbbexaNR5A1abx123820Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 1 (NR5A1)UnconjugatedWB17520 µlQ13285RUO
AbbexaNR5A1abx327956Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 1 (NR5A1)UnconjugatedELISA, WB187.550 µgQ13285RUO
AbbexaNR5A1abx114200Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1)UnconjugatedELISA, WB, IHC612.5100 µlQ13285RUO
AbbexaNR5A1abx235847Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 1 (NR5A1)UnconjugatedELISA, WB, IHC, IP350100 µgQ13285RUO
AbbexaNR5A2abx122664Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedELISA, WB337.5100 µgRUO
AbbexaNR5A2abx128253Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedWB, IHC, IF/ICC275100 µlO00482RUO
AbbexaNR5A2abx173379Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyHumanMonoclonalMouseNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedWB, IHC, IF/ICC787.51 mlRUO
AbbexaNR5A2abx430574Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyHumanPolyclonalGoatNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedP-ELISA, WB, IHC387.5200 µlRUO
AbbexaNR5A2abx315872Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody (Biotin)HumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)BiotinELISA162.520 µgO00482RUO
AbbexaNR5A2abx315871Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody (FITC)HumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)FITC162.520 µgO00482RUO
AbbexaNR5A2abx315870Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody (HRP)HumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)HRPELISA162.520 µgO00482RUO
AbbexaNR5A2abx318145Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedELISA, WB, IHC162.520 µgO00482RUO
AbbexaNR5A2abx004414Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedWB, IHC, IF/ICC17520 µlO00482RUO
AbbexaNR5A2abx235848Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyHumanPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedELISA, WB350100 µgO00482RUO
AbbexaNR5A2abx430414Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyHumanPolyclonalGoatNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedP-ELISA, WB387.5200 µlRUO
AbbexaNR5A2abx131388Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyRatPolyclonalRabbitNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedWB, IHC, IF/ICC287.5100 µlQ9QWM1RUO
AbbexaNR5A2abx173380Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) AntibodyRatMonoclonalMouseNuclear Receptor Subfamily 5 Group A Member 2 (NR5A2)UnconjugatedWB, IHC, IF/ICC8501 mlRUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaNR5A2abx650553Rat Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ProteinRatRecombinantE. coliUnconjugatedWB, SDS-PAGE22510 µgQ9QWM1RUO
AbbexaNR5A2abx166900Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE22510 µgRUO

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