NR5A - nuclear receptor subfamily 5 group A member | Elisa - Clia - Antibody - Protein
Family main features
Background
The NR5A family, also known as the nuclear receptor subfamily 5 group A, encompasses a group of orphan nuclear receptors that play pivotal roles in various physiological processes, including development, metabolism, and reproduction. This family includes two main members: NR5A1 (also known as Steroidogenic Factor-1, SF-1) and NR5A2 (also known as Liver Receptor Homolog-1, LRH-1). These receptors are highly conserved and are essential for the regulation of genes involved in steroidogenesis, bile acid synthesis, and glucose metabolism. NR5A receptors are expressed in a wide range of tissues, such as the adrenal glands, gonads, liver, and pancreas, highlighting their importance in endocrine and metabolic functions.
Protein Structure
The structure of NR5A receptors includes:
- N-terminal Domain (NTD): Contains activation function-1 (AF-1) domain, which is involved in ligand-independent transcriptional activation.
- DNA-binding Domain (DBD): Characterized by two zinc finger motifs that facilitate binding to specific DNA sequences, such as response elements in target gene promoters.
- Hinge Region: Connects the DBD to the ligand-binding domain (LBD) and includes nuclear localization signals.
- Ligand-binding Domain (LBD): This domain is essential for the receptor's interaction with co-regulators and potential ligands, although NR5A receptors are often classified as orphan receptors due to the absence of well-defined endogenous ligands.
Classification and Subtypes
The NR5A family consists of:
- NR5A1 (SF-1): Primarily involved in steroid hormone biosynthesis and sexual development.
- NR5A2 (LRH-1): Plays a crucial role in bile acid homeostasis, cholesterol metabolism, and glucose homeostasis.
Function and Biological Significance
- Steroidogenesis: NR5A1 regulates genes involved in the synthesis of steroid hormones, such as CYP11A1, which is crucial for the conversion of cholesterol to pregnenolone.
- Sexual Development: NR5A1 is essential for the development of the adrenal glands and gonads, influencing sex determination and differentiation.
- Metabolism: NR5A2 regulates genes involved in bile acid synthesis (e.g., CYP7A1) and glucose metabolism (e.g., PEPCK).
- Cell Proliferation and Differentiation: Both NR5A1 and NR5A2 are involved in cell proliferation and differentiation processes in various tissues, including the liver and pancreas.
Clinical Issues
- Congenital Adrenal Hyperplasia (CAH): Mutations in NR5A1 are linked to CAH, a condition characterized by impaired steroidogenesis.
- Disorders of Sexual Development (DSD): NR5A1 mutations can lead to gonadal dysgenesis and various forms of DSD.
- Cancer: NR5A2 has been implicated in various cancers, including pancreatic, colorectal, and breast cancers, where it may influence tumor growth and progression through its metabolic and proliferative functions.
- Metabolic Disorders: Dysregulation of NR5A2 can contribute to metabolic syndromes, including obesity, diabetes, and fatty liver disease.
Summary
The NR5A family of nuclear receptors, comprising NR5A1 and NR5A2, is integral to the regulation of steroidogenesis, sexual development, and metabolism. These receptors have a characteristic nuclear receptor structure with NTD, DBD, hinge region, and LBD. They bind to specific DNA sequences to regulate the expression of target genes involved in critical physiological processes. Clinical implications of NR5A dysregulation include congenital adrenal hyperplasia, disorders of sexual development, various cancers, and metabolic disorders. Understanding the roles and regulatory mechanisms of NR5A receptors is crucial for developing therapeutic strategies for related diseases.
NR5A1 Recommended name:
nuclear receptor subfamily 5 group A member 1 (NR5A1)
Aliases for NR5A1
ELP,SF1,FTZ1,POF7,SF-1,AD4BP,FTZF1,SPGF8,SRXX4,SRXY3,hSF-1,Steroidogenic factor 1,Fushi tarazu factor homolog 1,Nuclear receptor subfamily 5 group A member 1,Adrenal 4-binding protein
NR5A2 Recommended name:
nuclear receptor subfamily 5 group A member 2 (NR5A2)
Aliases for NR5A2
B1F.CPF,FTF,B1F2,LRH1,LRH-1,FTZ-F1,hB1F-2,FTZ-F1beta,Alpha-1-fetoprotein transcription factor,CYP7A promoter-binding factor,Hepatocytic transcription factor
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits, Proteins and Peptides, CLIA Kits) relacionados con NR5A - nuclear receptor subfamily 5 group A member
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immunoassays
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NR5A2 | abx512512 | Chicken Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA Kit | Chicken | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O42101 | RUO | ||
Abbexa | NR5A1 | abx351711 | Human Steroidogenic Factor 1 (NR5A1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 525 | 96 tests | Q13285 | RUO |
Abbexa | NR5A2 | abx152231 | Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | NR5A2 | abx512513 | Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 39 pg/ml | 687.5 | 96 tests | O00482 | RUO |
Abbexa | NR5A2 | abx494460 | Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.112 ng/ml | 845 | 96 tests | RUO | |
Abbexa | NR5A1 | abx353071 | Mouse Steroidogenic Factor 1 (NR5A1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 587.5 | 96 tests | P33242 | RUO |
Abbexa | NR5A2 | abx512514 | Mouse Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 39.1 pg/ml | 687.5 | 96 tests | P45448 | RUO |
Abbexa | NR5A1 | abx361805 | Pig Steroidogenic Factor 1 (NR5A1) ELISA Kit | Pig | Serum,Plasma,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | NR5A1 | abx353939 | Rat Steroidogenic Factor 1 (NR5A1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 587.5 | 96 tests | P50569 | RUO |
Abbexa | NR5A2 | abx494461 | Rat Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) CLIA Kit | Rat | Tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.063 ng/ml | 845 | 96 tests | RUO | |
Abbexa | NR5A2 | abx512515 | Rat Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.083 ng/ml | 687.5 | 96 tests | Q9QWM1 | RUO |
Abbexa | NR5A2 | abx155790 | Rat Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) ELISA Kit | Rat | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | RUO |
Primary Antibodies
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | NR5A1 | FNab05847 | anti- NR5A1 antibody | human | polyclonal | Rabbit | nuclear receptor subfamily 5, group A, member 1 | IgG | Unconjugated | ELISA, WB, IHC, IP | 100µg | Q13285 | RUO | |
FineTest | NR5A2 | FNab05848 | anti- NR5A2 antibody | human | polyclonal | Rabbit | nuclear receptor subfamily 5, group A, member 2 | IgG | Unconjugated | ELISA, WB | 100µg | O00482 | RUO | |
Abbexa | NR5A1 | abx032414 | Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) | Unconjugated | ELISA, WB, IHC, FCM | 250 | 80 µl | Q13285 | RUO | |
Abbexa | NR5A1 | abx123820 | Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) | Unconjugated | WB | 175 | 20 µl | Q13285 | RUO | |
Abbexa | NR5A1 | abx327956 | Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q13285 | RUO | |
Abbexa | NR5A1 | abx114200 | Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | Q13285 | RUO | |
Abbexa | NR5A1 | abx235847 | Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1) | Unconjugated | ELISA, WB, IHC, IP | 350 | 100 µg | Q13285 | RUO | |
Abbexa | NR5A2 | abx122664 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | NR5A2 | abx128253 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | O00482 | RUO | |
Abbexa | NR5A2 | abx173379 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Human | Monoclonal | Mouse | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | NR5A2 | abx430574 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Human | Polyclonal | Goat | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | NR5A2 | abx315872 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Biotin | ELISA | 162.5 | 20 µg | O00482 | RUO | |
Abbexa | NR5A2 | abx315871 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody (FITC) | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | FITC | 162.5 | 20 µg | O00482 | RUO | ||
Abbexa | NR5A2 | abx315870 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody (HRP) | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | HRP | ELISA | 162.5 | 20 µg | O00482 | RUO | |
Abbexa | NR5A2 | abx318145 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | ELISA, WB, IHC | 162.5 | 20 µg | O00482 | RUO | |
Abbexa | NR5A2 | abx004414 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | O00482 | RUO | |
Abbexa | NR5A2 | abx235848 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | ELISA, WB | 350 | 100 µg | O00482 | RUO | |
Abbexa | NR5A2 | abx430414 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Human | Polyclonal | Goat | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | NR5A2 | abx131388 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Rat | Polyclonal | Rabbit | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q9QWM1 | RUO | |
Abbexa | NR5A2 | abx173380 | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody | Rat | Monoclonal | Mouse | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) | Unconjugated | WB, IHC, IF/ICC | 850 | 1 ml | RUO |
Proteins and Peptides
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NR5A2 | abx650553 | Rat Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9QWM1 | RUO |
Abbexa | NR5A2 | abx166900 | Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO |
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