Human Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Protein

Background

Nuclear receptor subfamily 5 group A member 2 (NR5A2), also known as liver receptor homolog-1 (LRH-1), is a nuclear receptor involved in regulating the expression of genes responsible for bile acid metabolism, cholesterol homeostasis, and the function of the liver and intestine NR5A2 is expressed in tissues such as the liver, pancreas, and ovaries, where it regulates the synthesis and metabolism of cholesterol and bile acids It also plays an essential role in the differentiation of hepatocytes and the maintenance of liver function, including processes like gluconeogenesis and lipid metabolism NR5A2 is involved in controlling the transcription of genes that influence energy metabolism, steroidogenesis, and inflammatory responses Dysregulation of NR5A2 can lead to metabolic disorders, including dyslipidemia and liver disease, and has also been implicated in some cancers, particularly liver and ovarian cancers The role of NR5A2 in maintaining metabolic homeostasis and regulating bile acid synthesis makes it an important target for therapies aimed at treating metabolic and liver-related diseases