Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody
364€ (100 µg)
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935106861
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name
Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx235848
tested applications
ELISA, WB
Description
NR5A2 Antibody is a Rabbit Polyclonal against NR5A2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00482 |
| Gene ID | 2494 |
| OMIM | 604453 |
| Alias | ELP,SF1,FTZ1,POF7,SF-1,AD4BP,FTZF1,SPGF8,SRXX4,SRXY3,hSF-1,Steroidogenic factor 1,Fushi tarazu factor homolog 1,Nuclear receptor subfamily 5 group A member 1,Adrenal 4-binding protein |
| Background | Antibody anti-NR5A2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Nuclear receptor subfamily 5 group A member 2 (NR5A2), also known as liver receptor homolog-1 (LRH-1), is a nuclear receptor involved in regulating the expression of genes responsible for bile acid metabolism, cholesterol homeostasis, and the function of the liver and intestine NR5A2 is expressed in tissues such as the liver, pancreas, and ovaries, where it regulates the synthesis and metabolism of cholesterol and bile acids It also plays an essential role in the differentiation of hepatocytes and the maintenance of liver function, including processes like gluconeogenesis and lipid metabolism NR5A2 is involved in controlling the transcription of genes that influence energy metabolism, steroidogenesis, and inflammatory responses Dysregulation of NR5A2 can lead to metabolic disorders, including dyslipidemia and liver disease, and has also been implicated in some cancers, particularly liver and ovarian cancers The role of NR5A2 in maintaining metabolic homeostasis and regulating bile acid synthesis makes it an important target for therapies aimed at treating metabolic and liver-related diseases
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