NPBWR - Neuropeptides B/W receptor type | Elisa - Clia - Antibody - Protein

Background:

Neuropeptides B/W Receptor Type (NPBWR) is a G protein-coupled receptor (GPCR) involved in the regulation of various physiological processes through its interactions with neuropeptides B and W. NPBWR, also known as NPBWR1, is a GPCR that was identified in the early 2000s as the receptor for neuropeptides B and W. NPBWR was discovered through bioinformatics and molecular cloning techniques aimed at identifying novel GPCRs. NPBWR is expressed in various regions of the brain, including the hypothalamus, amygdala, and hippocampus, as well as in peripheral tissues. NPBWR primarily binds to neuropeptides B (NPB) and W (NPW), which are endogenous peptide ligands involved in the regulation of energy homeostasis, stress responses, and neuroendocrine function.In summary, NPBWR, also known as NPBWR1, is a GPCR involved in the regulation of energy homeostasis, stress responses, and neuroendocrine function through its interactions with neuropeptides B and W. Dysregulation of NPBWR signaling has been implicated in various pathological conditions, including mood disorders, obesity, and stress-related disorders, highlighting its potential as a therapeutic target for these conditions.

Structural Features:

NPBWR is a typical GPCR with seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus.The receptor undergoes conformational changes upon ligand binding, leading to the activation of intracellular signaling pathways.

Subtypes and Classification:

• NPBWR1: This receptor subtype is the primary target for neuropeptides B and W. It is also known as GPR7, and it mediates the physiological effects of NPB and NPW.

Physiological Functions:

• Regulation of Energy Homeostasis: NPBWR signaling is involved in the regulation of feeding behavior, energy expenditure, and body weight control.
• Neuroendocrine Function: NPBWR activation modulates neuroendocrine responses, including the release of hormones such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and arginine vasopressin (AVP).
• Stress Responses: NPBWR is implicated in stress responses, anxiety-related behaviors, and the hypothalamic-pituitary-adrenal (HPA) axis.
• Reproductive Function: NPBWR signaling may play roles in reproductive function, although its specific functions in this regard are not fully understood.

Clinical Implications:

• Mood Disorders: Dysregulation of NPBWR signaling has been implicated in mood disorders such as depression and anxiety, making it a potential target for mood disorder therapies.
• Obesity and Metabolic Disorders: NPBWR has been implicated in the regulation of energy balance and body weight, suggesting potential therapeutic implications for obesity and metabolic disorders.
• Stress-related Disorders: NPBWR signaling is involved in stress responses and HPA axis regulation, suggesting potential implications for stress-related disorders such as post-traumatic stress disorder (PTSD) and anxiety disorders.

Therapeutic Potential:

• Drug Development: NPBWR agonists and antagonists are being investigated for their potential therapeutic applications in mood disorders, obesity, and stress-related disorders.
• Precision Medicine: Targeting NPBWR signaling pathways may offer personalized treatment strategies for individuals with mood disorders, obesity, or stress-related conditions.